Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FABP4_HUMAN
Description:fatty acid binding protein 4, adipocyte [Source:HGNC Symbol;Acc:3559]
Location:chr8 q21.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y20ENFDDyMKEVGLipocalinPhosphoSitePlus
Y20ENFDDyMKEVGTyr-kinases RegPhos
Y20ENFDDyMKEVGphosphoELM; RegPhos
Y129TSTRVyERARegPhos
Y129TSTRVyERA__LipocalinPhosphoSitePlus
Y20ENFDDyMKEVGINSRHPRD; RegPhos
T104DGKSTtIKRKRLipocalinPhosphoSitePlus
T103WDGKStTIKRKLipocalinPhosphoSitePlus
Y129TSTRVyEphosphoELM

Dephosphorylation site
FABP4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256104*133KCOSMICMelanoma21499247
ENSP00000256104E23DSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000256104V119ICOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000256104Breast CancerMetastasistissueDown0.4719053527
ENSP00000256104Breast CancerMetastasistissueDown0.4119053527
ENSP00000256104Breast CancerNormal vs. CancertissueDown<0.115767701
ENSP00000256104breast ductal carcinomaNormal vs. CancertissueDown0.001120534901

Hyperphosphorylation site
FABP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANFABP4_HUMANkinase -> substrateRegPhos
INSR_HUMANFABP4_HUMANkinase -> substrateHPRD; RegPhos
NEK6_HUMANFABP4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03320PPAR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005811lipid particleTAScellular_component
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0042632cholesterol homeostasisIEAbiological_process
GO:0001816cytokine productionIEAbiological_process
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005504fatty acid bindingTASmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0050872white fat cell differentiationIEAbiological_process
GO:0005215transporter activityIEAmolecular_function
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0019433triglyceride catabolic processTASbiological_process
GO:0005634nucleusIEAcellular_component


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