| UniProt/SwissProt ID: | FABP4_HUMAN |
| Description: | fatty acid binding protein 4, adipocyte [Source:HGNC Symbol;Acc:3559] |
| Location: | chr8 q21.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y20 | ENFDDyMKEVG | Lipocalin | PhosphoSitePlus |
| Y20 | ENFDDyMKEVG | Tyr-kinases | RegPhos |
| Y20 | ENFDDyMKEVG | phosphoELM; RegPhos | |
| Y129 | TSTRVyERA | RegPhos | |
| Y129 | TSTRVyERA__ | Lipocalin | PhosphoSitePlus |
| Y20 | ENFDDyMKEVG | INSR | HPRD; RegPhos |
| T104 | DGKSTtIKRKR | Lipocalin | PhosphoSitePlus |
| T103 | WDGKStTIKRK | Lipocalin | PhosphoSitePlus |
| Y129 | TSTRVyE | phosphoELM | |
| Dephosphorylation site |
| FABP4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256104 | *133K | COSMIC | Melanoma | 21499247 | ENSP00000256104 | E23D | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000256104 | V119I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000256104 | Breast Cancer | Metastasis | tissue | Down | 0.47 | 19053527 | ENSP00000256104 | Breast Cancer | Metastasis | tissue | Down | 0.41 | 19053527 | ENSP00000256104 | Breast Cancer | Normal vs. Cancer | tissue | Down | <0.1 | 15767701 | ENSP00000256104 | breast ductal carcinoma | Normal vs. Cancer | tissue | Down | 0.0011 | 20534901 |
| Hyperphosphorylation site |
| FABP4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | FABP4_HUMAN | kinase -> substrate | RegPhos |
| INSR_HUMAN | FABP4_HUMAN | kinase -> substrate | HPRD; RegPhos |
| NEK6_HUMAN | FABP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03320 | PPAR signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005811 | lipid particle | TAS | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0050729 | positive regulation of inflammatory response | IEA | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | IEA | biological_process |
| GO:0006629 | lipid metabolic process | TAS | biological_process |
| GO:0042632 | cholesterol homeostasis | IEA | biological_process |
| GO:0001816 | cytokine production | IEA | biological_process |
| GO:0071285 | cellular response to lithium ion | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005504 | fatty acid binding | TAS | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0050872 | white fat cell differentiation | IEA | biological_process |
| GO:0005215 | transporter activity | IEA | molecular_function |
| GO:0050873 | brown fat cell differentiation | IEA | biological_process |
| GO:0019433 | triglyceride catabolic process | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |