Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SH2B2_HUMAN
Description:SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:17381]
Location:chr7 q22.1
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S598RSRSNsAERLLAKT1RegPhos
S641RSRSNsAERLLAKT1HPRD
Y629AVENQySFY__PhosphoSitePlus
S136VRKGFsLRNMSPhosphoSitePlus
Y629AVENQySFYRegPhos

Dephosphorylation site
SH2B2_HUMAN do not have dephosphorylation site.

Mutation site
SH2B2_HUMAN do not have mutation site.

Differential expressed protein
SH2B2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SH2B2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSH2B2_HUMANkinase -> substrateRegPhos
AKT1_HUMANSH2B2_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANSH2B2_HUMANkinase -> substrateKEGG
SH2B2_HUMANCBLC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0050851antigen receptor-mediated signaling pathwayIEAbiological_process
GO:0019222regulation of metabolic processIEAbiological_process
GO:0008269JAK pathway signal transduction adaptor activityIDAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0046425regulation of JAK-STAT cascadeIDAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0001725stress fiberIEAcellular_component
GO:0005070SH3/SH2 adaptor activityIEAmolecular_function
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0001922B-1 B cell homeostasisIEAbiological_process
GO:0001726ruffleIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0046578regulation of Ras protein signal transductionIEAbiological_process
GO:0005068transmembrane receptor protein tyrosine kinase adaIEAmolecular_function
GO:0005884actin filamentIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function


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