Phosphorylation

Protein information

UniProt/SwissProt ID:	SH2B2_HUMAN
Description:	SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:17381]
Location:	chr7 q22.1
Node attribute:	substrate; PPI(source)

Position	PhosphoPeptide	Catalytic kinase	Source
S598	RSRSNsAERLL	AKT1	RegPhos
S641	RSRSNsAERLL	AKT1	HPRD
Y629	AVENQySFY__		PhosphoSitePlus
S136	VRKGFsLRNMS		PhosphoSitePlus
Y629	AVENQySFY		RegPhos

SH2B2_HUMAN do not have dephosphorylation site.

SH2B2_HUMAN do not have mutation site.

SH2B2_HUMAN is not differential expressed protein.

SH2B2_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
ZAGL2_HUMAN	SH2B2_HUMAN	kinase -> substrate	RegPhos
AKT1_HUMAN	SH2B2_HUMAN	kinase -> substrate	HPRD; RegPhos
INSR_HUMAN	SH2B2_HUMAN	kinase -> substrate	KEGG
SH2B2_HUMAN	CBLC_HUMAN	other	KEGG

KEGG Pathway

KEGG ID	Pathway
hsa04910	Insulin signaling pathway
hsa04722	Neurotrophin signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0005515	protein binding	IEA	molecular_function
GO:0050851	antigen receptor-mediated signaling pathway	IEA	biological_process
GO:0019222	regulation of metabolic process	IEA	biological_process
GO:0008269	JAK pathway signal transduction adaptor activity	IDA	molecular_function
GO:0005543	phospholipid binding	IEA	molecular_function
GO:0046425	regulation of JAK-STAT cascade	IDA	biological_process
GO:0007399	nervous system development	IEA	biological_process
GO:0019221	cytokine-mediated signaling pathway	IEA	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0001725	stress fiber	IEA	cellular_component
GO:0005070	SH3/SH2 adaptor activity	IEA	molecular_function
GO:0008286	insulin receptor signaling pathway	IEA	biological_process
GO:0035556	intracellular signal transduction	IEA	biological_process
GO:0001922	B-1 B cell homeostasis	IEA	biological_process
GO:0001726	ruffle	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0007165	signal transduction	TAS	biological_process
GO:0050873	brown fat cell differentiation	IEA	biological_process
GO:0030036	actin cytoskeleton organization	IEA	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0046578	regulation of Ras protein signal transduction	IEA	biological_process
GO:0005068	transmembrane receptor protein tyrosine kinase ada	IEA	molecular_function
GO:0005884	actin filament	IEA	cellular_component
GO:0007596	blood coagulation	TAS	biological_process
GO:0004871	signal transducer activity	IEA	molecular_function

Human Phosphorylation Mediated
Signaling Transduction Network