Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IKBA_HUMAN
Description:nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [Source:HGNC Symbol;Acc:7797]
Location:chr14 q13.2
Node attribute:PPI(target); PPI(source); ubiquitination(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y42MKDEEyEQMVKLCKHPRD; RegPhos
S36DSGLDsMKDEEIKKeRegPhos
S32DDRHDsGLDSMIKKbRegPhos
S32DDRHDsGLDSMIKKaRegPhos
S32DDRHDsGLDSMIKKeRegPhos
S32DDRHDsGLDSMPhosphoSitePlus; phosphoELM
S283QMLPEsEDEESCK2_alphaphosphoELM
S293SYDTEsEFTEFCK2a1(CK2 alphaRegPhos
S32DDRHDsGLDSMIKK_groupphosphoELM; RegPhos
S32DDRHDsGLDSMCSNK2A1HPRD
S283QMLPEsEDEESCK2a1-rsRegPhos
S288SEDEEsYDTESCK2a1(CK2 alphaRegPhos
S36DSGLDsMKDEEIKKaRegPhos
T291EESYDtESEFTPhosphoSitePlus
S293SYDTEsEFTEFCK2a1-rsRegPhos
T291EESYDtESEFTCK2_groupphosphoELM; RegPhos
S283QMLPEsEDEESCK2a1RegPhos
S36DSGLDsMKDEEIKKa(IKK alphaRegPhos
S293SYDTEsEFTEFPhosphoSitePlus
T291EESYDtESEFTCK2a1RegPhos
T291EESYDtESEFTCK2a1-rsRegPhos
T291EESYDtESEFTCK2a1(CK2 alphaRegPhos
S32DDRHDsGLDSMEIF2AK2HPRD
S32DDRHDsGLDSMIKKa(IKK alphaRegPhos
S32DDRHDsGLDSMCK2a1-rsRegPhos
S288SEDEEsYDTESCSNK2A1HPRD
S293SYDTEsEFTEFCK2a1RegPhos
Y305EDELPyDDCVFABL1RegPhos
S32DDRHDsGLDSMCK2_groupphosphoELM; RegPhos
T90EEKALtMEVIRAnk_2PhosphoSitePlus
S283QMLPEsEDEESCSNK2A1HPRD
S36DSGLDsMKDEECK2_groupphosphoELM; RegPhos
S32DDRHDsGLDSMO15382(Branched-chain amiRegPhos
S283QMLPEsEDEESCK2_groupphosphoELM; RegPhos
S283QMLPEsEDEESPhosphoSitePlus
S32DDRHDsGLDSMRSK3RegPhos
S36DSGLDsMKDEEIKKbRegPhos
S36DSGLDsMKDEECK2a1-rsRegPhos
S283QMLPEsEDEESCK2a1(CK2 alphaRegPhos
S32DDRHDsGLDSMIKBKGHPRD
S36DSGLDsMKDEEPhosphoSitePlus; phosphoELM
T291EESYDtESEFTCSNK2A1HPRD
S32DDRHDsGLDSMPKR(EIF2AK2RegPhos
S36DSGLDsMKDEECK2a1RegPhos
Y42MKDEEyEQMVKSrcRegPhos
S32DDRHDsGLDSMCK2a1RegPhos
S288SEDEEsYDTESCK2_alphaphosphoELM
S36DSGLDsMKDEEIKK_groupphosphoELM; RegPhos
T90EEKALtMEVIRHPRD
S36DSGLDsMKDEETBK1HPRD; RegPhos
Y305EDELPyDDCVFAblphosphoELM
S288SEDEEsYDTESCK2a1-rsRegPhos
S32DDRHDsGLDSMPKRRegPhos
Y42MKDEEyEQMVKTyr-kinasesRegPhos
T299EFTEFtEDELPPhosphoSitePlus
T291EESYDtESEFTCK2_alphaphosphoELM
Y42MKDEEyEQMVKPhosphoSitePlus; phosphoELM
S293SYDTEsEFTEFCSNK2A1HPRD
Y42MKDEEyEQMVKLckphosphoELM; RegPhos
S288SEDEEsYDTESPhosphoSitePlus
Y305EDELPyDDCVFPhosphoSitePlus
S293SYDTEsEFTEFCK2_alphaphosphoELM
S288SEDEEsYDTESCK2a1RegPhos
S32DDRHDsGLDSMRPS6KA1HPRD
S36DSGLDsMKDEECSNK2A1HPRD
S36DSGLDsMKDEEIKBKBHPRD
Y42MKDEEyEQMVKSRCHPRD; phosphoELM; RegPhos
S36DSGLDsMKDEEIKBKEHPRD
S32DDRHDsGLDSMIKBKBHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y42DSMKDEEyEQMVKELPTPN13HPRD

Mutation site
IKBA_HUMAN do not have mutation site.

Differential expressed protein
IKBA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IKBA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TBK1_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
BTK_HUMANIKBA_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANIKBA_HUMANkinase -> substrateRegPhos
SRC_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; NetPath
IKKA_HUMANIKBA_HUMANkinase -> substrateNetPath
M3K3_HUMANIKBA_HUMANkinase -> substrateNetPath
M3K2_HUMANIKBA_HUMANkinase -> substrateNetPath
KS6A1_HUMANIKBA_HUMANkinase -> substrateHPRD
IKKB_HUMANIKBA_HUMANkinase -> substrateNetPath
CSK21_HUMANIKBA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ABL1_HUMANIKBA_HUMANkinase -> substrateRegPhos
E2AK2_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
M3K1_HUMANIKBA_HUMANkinase -> substrateNetPath
LCK_HUMANIKBA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
NEMO_HUMANIKBA_HUMANkinase -> substrateHPRD
IKKE_HUMANIKBA_HUMANkinase -> substrateHPRD
PTN13_HUMANIKBA_HUMANphosphatase -> substrateHPRD
UB2D3_HUMANIKBA_HUMANubiquitinationNetPath
FBW1A_HUMANIKBA_HUMANubiquitinationNetPath
UB2R1_HUMANIKBA_HUMANubiquitinationNetPath
UB2D2_HUMANIKBA_HUMANubiquitinationNetPath
FBW1B_HUMANIKBA_HUMANubiquitinationNetPath
HSPB1_HUMANIKBA_HUMANubiquitinationNetPath
IKBA_HUMANNFKB1_HUMANotherKEGG
NFKB1_HUMANIKBA_HUMANotherKEGG
SUH_HUMANIKBA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05145Toxoplasmosis
hsa05200Pathways in cancer
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04380Osteoclast differentiation
hsa04064NF-kappa B signaling pathway
hsa05166HTLV-I infection
hsa04622RIG-I-like receptor signaling pathway
hsa05222Small cell lung cancer
hsa04620Toll-like receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa05162Measles
hsa04722Neurotrophin signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04920Adipocytokine signaling pathway
hsa05160Hepatitis C
hsa05168Herpes simplex infection
hsa04660T cell receptor signaling pathway
hsa05215Prostate cancer
hsa05140Leishmaniasis
hsa05164Influenza A
hsa04623Cytosolic DNA-sensing pathway
hsa05169Epstein-Barr virus infection
hsa04210Apoptosis
hsa04062Chemokine signaling pathway
hsa05134Legionellosis
hsa05131Shigellosis
hsa05220Chronic myeloid leukemia
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0010745negative regulation of macrophage derived foam celIMPbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0031072heat shock protein bindingIEAmolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0042994cytoplasmic sequestering of transcription factorIDAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process
GO:0033256I-kappaB/NF-kappaB complexTAScellular_component
GO:0008139nuclear localization sequence bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0010875positive regulation of cholesterol effluxIMPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:0000060protein import into nucleus, translocationIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0045638negative regulation of myeloid cell differentiatioIEAbiological_process
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0051059NF-kappaB bindingIEAmolecular_function
GO:0042345regulation of NF-kappaB import into nucleusNASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayIEAbiological_process
GO:0010888negative regulation of lipid storageIMPbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0045746negative regulation of Notch signaling pathwayIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0070427nucleotide-binding oligomerization domain containiIEAbiological_process
GO:0032495response to muramyl dipeptideIEAbiological_process
GO:0070417cellular response to coldNASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0070431nucleotide-binding oligomerization domain containiIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0007253cytoplasmic sequestering of NF-kappaBIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0008134transcription factor bindingTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0032270positive regulation of cellular protein metabolic IMPbiological_process
GO:0043392negative regulation of DNA bindingNASbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process