Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FBW1A_HUMAN
Description:beta-transducin repeat containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:1144]
Location:chr10 q24.32
Node attribute:kinase; ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y600SPSRTyTYISRPhosphoSitePlus
S604TYTYIsR____PhosphoSitePlus
S555TLVEHsGRVFRWD40PhosphoSitePlus
Y602SRTYTyISR__PhosphoSitePlus
Y474IACLQyRDRLVWD40PhosphoSitePlus
T599RSPSRtYTYISPhosphoSitePlus

Dephosphorylation site
FBW1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359206P66SCOSMICOvarian Cancer21720365
ENSP00000359206F514YCOSMICOvarian Cancer21720365
ENSP00000359206M232VBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000385339M196VBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
FBW1A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FBW1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FBW1A_HUMANNFKB1_HUMANkinase -> substrateNetPath
FBW1A_HUMANIKBA_HUMANubiquitinationNetPath
FBW1A_HUMANIKBB_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05131Shigellosis
hsa04340Hedgehog signaling pathway
hsa04310Wnt signaling pathway
hsa04114Oocyte meiosis
hsa04710Circadian rhythm - mammal
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033598mammary gland epithelial cell proliferationIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiTASbiological_process
GO:0030163protein catabolic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0051726regulation of cell cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016567protein ubiquitinationIDAbiological_process
GO:0045879negative regulation of smoothened signaling pathwaTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0031648protein destabilizationIMPbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0061136regulation of proteasomal protein catabolic procesIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0042753positive regulation of circadian rhythmIEAbiological_process
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeIEAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0045862positive regulation of proteolysisIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0000209protein polyubiquitinationIEAbiological_process
GO:0045309protein phosphorylated amino acid bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0019005SCF ubiquitin ligase complexIDAcellular_component
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0006511ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0008013beta-catenin bindingIEAmolecular_function


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