Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K3_HUMAN
Description:mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:6855]
Location:chr17 q23.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S147IKASQsAGDINPhosphoSitePlus
S145VRIKAsQSAGDPhosphoSitePlus; HPRD
S464GALTEsVTRKYPkinasePhosphoSitePlus
S194IARQGsYTSINPhosphoSitePlus
S161RNHNSsSPHSGHPRD
Y319VHHKDySDGRRHPRD
T294SDGRRtFPRIRPhosphoSitePlus; HPRD; RegPhos
S526GTGMRsVTGTPPkinasePhosphoSitePlus
S557GTGMRsVTGTPMAP3K3HPRD
T274GVKGGtYPRRYPhosphoSitePlus
S166RSRHLsVSSQNPKACaRegPhos
S355NVPTKsPSAPIPhosphoSitePlus; HPRD; SysPTM
S386NVPTKsPSAPIHPRD
T325SDGRRtFPRIRHPRD
T530RSVTGtPYWMSPkinasePhosphoSitePlus
S337RGRLRsADSENPRKACAHPRD
S206QNPGRsSPPPGHPRD
S207NPGRSsPPPGYHPRD
Y288VHHKDySDGRRHPRD; RegPhos
S234QSLDRsADSPSPhosphoSitePlus; HPRD
S168RHLSVsSQNPGPhosphoSitePlus; HPRD
S166RSRHLsVSSQNSGK_groupphosphoELM; RegPhos
Y275VKGGTyPRRYHPhosphoSitePlus
S162PPEPRsRHLSVPhosphoSitePlus
Y427ERIVQyYGCLRPkinasePhosphoSitePlus
S526GTGMRsVTGTPMAP3K3HPRD; RegPhos
S197QGSYTsINSEGPKACaRegPhos
S281MSRAQsFPDNRHPRD
T353ERNVPtKSPSAHPRD
Y428RIVQYyGCLRDPkinasePhosphoSitePlus
S175QNPGRsSPPPGPhosphoSitePlus; HPRD
S176VRIKAsQSAGDHPRD
Y155DINTIyQPPEPPhosphoSitePlus
T530RSVTGtPYWMSRegPhos
S320HHKDYsDGRRTHPRD
S337RGRLRsADSENPKACaRegPhos
S176NPGRSsPPPGYPhosphoSitePlus; HPRD
S250MSRAQsFPDNRPhosphoSitePlus; HPRD
S520QTICMsGTGMRPkinasePhosphoSitePlus
S237DRSADsPSFRKPhosphoSitePlus; HPRD
T516SKRLQtICMSGPkinasePhosphoSitePlus
S166RSRHLsVSSQNPKA_groupRegPhos
S268DRSADsPSFRKHPRD
S340LRSADsENALSPhosphoSitePlus; HPRD; RegPhos
S337RGRLRsADSENPhosphoSitePlus; phosphoELM; RegPhos
T528GMRSVtGTPYWPkinasePhosphoSitePlus
S314VPSSRsLSTNGPhosphoSitePlus; HPRD
S357PTKSPsAPINWPhosphoSitePlus
S371LRSADsENALSHPRD
S316SSRSLsTNGENPhosphoSitePlus
S166RSRHLsVSSQNPhosphoSitePlus; phosphoELM
T317SRSLStNGENMPhosphoSitePlus
S289HHKDYsDGRRTHPRD; RegPhos
S131NHNSSsPHSGVPhosphoSitePlus; HPRD
S169HLSVSsQNPGRPhosphoSitePlus
S199RHLSVsSQNPGHPRD
S166RSRHLsVSSQNPRKACAHPRD
S162NHNSSsPHSGVHPRD
S337RGRLRsADSENSGK_groupphosphoELM; RegPhos
S345VPSSRsLSTNGHPRD
T384ERNVPtKSPSAHPRD
S130RNHNSsSPHSGPhosphoSitePlus; HPRD
Y445TIFMEyMPGGSPkinasePhosphoSitePlus
S197RSRHLsVSSQNPRKACAHPRD
S337RGRLRsADSENPKA_groupRegPhos
S265QSLDRsADSPSHPRD
S368RGRLRsADSENPRKACAHPRD

Dephosphorylation site
M3K3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354927R628WDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354927R465LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000354485L416ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
M3K3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANM3K3_HUMANkinase -> substrateRegPhos
M3K3_HUMANM3K3_HUMANkinase -> substrateHPRD; RegPhos
M3K3_HUMANIKBA_HUMANkinase -> substrateNetPath
M3K3_HUMANIKKB_HUMANkinase -> substrateNetPath
KPCA_HUMANM3K3_HUMANkinase -> substrateHPRD
SGK1_HUMANM3K3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa05166HTLV-I infection
hsa04912GnRH signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0005829cytosolTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0000186activation of MAPKK activityTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000165MAPK cascadeTASbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0046777protein autophosphorylationIDAbiological_process


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