| UniProt/SwissProt ID: | IKKE_HUMAN |
| Description: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [Source:HGNC Symbol;Acc:14552] |
| Location: | chr1 q32.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S172 | DEKFVsVYGTE | Pkinase | PhosphoSitePlus |
| S479 | TERFSsVAGTP | DUF4206 | PhosphoSitePlus |
| Y179 | YGTEEyLHPDM | Pkinase | PhosphoSitePlus |
| S172 | DEKFVsVYGTE | phosphoELM | |
| T474 | SSSLGtERFSS | DUF4206 | PhosphoSitePlus |
| S664 | KGAQAsPPPIA | PhosphoSitePlus; HPRD | |
| Y671 | PPIAPyPSPTR | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| IKKE_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356087 | R525P | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000444529 | A286V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356087 | V365I | BIOMART | Brain Cancer | 21930507, 21930502 |
| Differential expressed protein |
| IKKE_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IKKE_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IKKE_HUMAN | IKBA_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05162 | Measles |
| hsa04623 | Cytosolic DNA-sensing pathway |
| hsa05160 | Hepatitis C |
| hsa05168 | Herpes simplex infection |
| hsa05164 | Influenza A |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010008 | endosome membrane | TAS | cellular_component |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0032480 | negative regulation of type I interferon productio | TAS | biological_process |
| GO:0004704 | NF-kappaB-inducing kinase activity | IDA | molecular_function |
| GO:0008630 | intrinsic apoptotic signaling pathway in response | IMP | biological_process |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0002756 | MyD88-independent toll-like receptor signaling pat | TAS | biological_process |
| GO:0008384 | IkappaB kinase activity | IEA | molecular_function |
| GO:0034138 | toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IEP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006955 | immune response | NAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007252 | I-kappaB phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0038061 | NIK/NF-kappaB cascade | IDA | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathwa | TAS | biological_process |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |