Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K1_HUMAN
Description:mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:6848]
Location:chr5 q11.2
Node attribute:ubiquitination(target); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S923TKLSAsSEDISPhosphoSitePlus
S154PAAEPsPAAAPPhosphoSitePlus
T665AMLVYtPCHSLPhosphoSitePlus
T999PAGTAtDVSKHPhosphoSitePlus
S252GRRSPsPGNSPPhosphoSitePlus
T850SSTHFtRMRRRPhosphoSitePlus
S844EMLSVsSSTHFPhosphoSitePlus
S292PRRAPsPDGFSPhosphoSitePlus; phosphoELM
S1157EVAVLsPEKAEPhosphoSitePlus
S1089DLNSSsKCDDSPhosphoSitePlus
S242QASAAsPASKGPhosphoSitePlus
T542SNFNLtHYGTQPhosphoSitePlus
S1026TQRKFsLQFHRPhosphoSitePlus
S133VAAPDsGASSPPhosphoSitePlus
S21GARATsPEAGGPhosphoSitePlus
T20PGARAtSPEAGPhosphoSitePlus
S1018RIPSAsPQTQRPhosphoSitePlus
S300GFSPYsPEETNPhosphoSitePlus; phosphoELM
S1087TLDLNsSSKCDPhosphoSitePlus
S333LIGGDsPDNKYPhosphoSitePlus
S1016PCRIPsASPQTPhosphoSitePlus
T1114DETVFtPVEEKPhosphoSitePlus
S275RRKRVsPVPFQPhosphoSitePlus
S232HLAAEsPGEVQPhosphoSitePlus
S1043DSDKLsPVFTQPhosphoSitePlus
S250SKGRRsPSPGNPhosphoSitePlus
S281PVPFQsGRITPPhosphoSitePlus
Y1338HLLSKyGAFKEPkinasePhosphoSitePlus
S297SPDGFsPYSPEPhosphoSitePlus; phosphoELM
S511SSPVDsPSSLRPhosphoSitePlus; phosphoELM
T285QSGRItPPRRAPhosphoSitePlus
S67LRKVRsVELDQPhosphoSitePlus
S796YKKLLsLLTFAPhosphoSitePlus
T657VAALKtLRAMLPhosphoSitePlus
S35ALKASsAPAAAPhosphoSitePlus
T1082SKNSMtLDLNSPhosphoSitePlus
S507SHELSsPVDSPPhosphoSitePlus; phosphoELM

Dephosphorylation site
M3K1_HUMAN do not have dephosphorylation site.

Mutation site
M3K1_HUMAN do not have mutation site.

Differential expressed protein
M3K1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M4K3_HUMANM3K1_HUMANkinase -> substrateKEGG
M3K1_HUMANIKKA_HUMANkinase -> substrateKEGG
M3K1_HUMANMP2K7_HUMANkinase -> substrateRegPhos
M3K1_HUMANMP2K4_HUMANkinase -> substrateKEGG
RIPK1_HUMANM3K1_HUMANkinase -> substrateNetPath
M3K1_HUMANMP2K1_HUMANkinase -> substrateKEGG
M4K4_HUMANM3K1_HUMANkinase -> substrateKEGG
M3K1_HUMANIKBA_HUMANkinase -> substrateNetPath
M3K1_HUMANMP2K2_HUMANkinase -> substrateKEGG
M3K1_HUMANM3K1_HUMANkinase -> substrateNetPath
DTX1_HUMANM3K1_HUMANubiquitinationNetPath
CDC42_HUMANM3K1_HUMANotherKEGG
RAC1_HUMANM3K1_HUMANotherKEGG
TRAF2_HUMANM3K1_HUMANotherKEGG
CASP3_HUMANM3K1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0000186activation of MAPKK activityNASbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0008545JUN kinase kinase activityIEAmolecular_function
GO:0043010camera-type eye developmentIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0007254JNK cascadeIEAbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0006468protein phosphorylationNASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0042060wound healingIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0004709MAP kinase kinase kinase activityNASmolecular_function
GO:0008063Toll signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0007257activation of JUN kinase activityIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008637apoptotic mitochondrial changesIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005524ATP bindingNASmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process


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