| UniProt/SwissProt ID: | M3K1_HUMAN |
| Description: | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:6848] |
| Location: | chr5 q11.2 |
| Node attribute: | ubiquitination(target); substrate; kinase; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S923 | TKLSAsSEDIS | PhosphoSitePlus | |
| S154 | PAAEPsPAAAP | PhosphoSitePlus | |
| T665 | AMLVYtPCHSL | PhosphoSitePlus | |
| T999 | PAGTAtDVSKH | PhosphoSitePlus | |
| S252 | GRRSPsPGNSP | PhosphoSitePlus | |
| T850 | SSTHFtRMRRR | PhosphoSitePlus | |
| S844 | EMLSVsSSTHF | PhosphoSitePlus | |
| S292 | PRRAPsPDGFS | PhosphoSitePlus; phosphoELM | |
| S1157 | EVAVLsPEKAE | PhosphoSitePlus | |
| S1089 | DLNSSsKCDDS | PhosphoSitePlus | |
| S242 | QASAAsPASKG | PhosphoSitePlus | |
| T542 | SNFNLtHYGTQ | PhosphoSitePlus | |
| S1026 | TQRKFsLQFHR | PhosphoSitePlus | |
| S133 | VAAPDsGASSP | PhosphoSitePlus | |
| S21 | GARATsPEAGG | PhosphoSitePlus | |
| T20 | PGARAtSPEAG | PhosphoSitePlus | |
| S1018 | RIPSAsPQTQR | PhosphoSitePlus | |
| S300 | GFSPYsPEETN | PhosphoSitePlus; phosphoELM | |
| S1087 | TLDLNsSSKCD | PhosphoSitePlus | |
| S333 | LIGGDsPDNKY | PhosphoSitePlus | |
| S1016 | PCRIPsASPQT | PhosphoSitePlus | |
| T1114 | DETVFtPVEEK | PhosphoSitePlus | |
| S275 | RRKRVsPVPFQ | PhosphoSitePlus | |
| S232 | HLAAEsPGEVQ | PhosphoSitePlus | |
| S1043 | DSDKLsPVFTQ | PhosphoSitePlus | |
| S250 | SKGRRsPSPGN | PhosphoSitePlus | |
| S281 | PVPFQsGRITP | PhosphoSitePlus | |
| Y1338 | HLLSKyGAFKE | Pkinase | PhosphoSitePlus |
| S297 | SPDGFsPYSPE | PhosphoSitePlus; phosphoELM | |
| S511 | SSPVDsPSSLR | PhosphoSitePlus; phosphoELM | |
| T285 | QSGRItPPRRA | PhosphoSitePlus | |
| S67 | LRKVRsVELDQ | PhosphoSitePlus | |
| S796 | YKKLLsLLTFA | PhosphoSitePlus | |
| T657 | VAALKtLRAML | PhosphoSitePlus | |
| S35 | ALKASsAPAAA | PhosphoSitePlus | |
| T1082 | SKNSMtLDLNS | PhosphoSitePlus | |
| S507 | SHELSsPVDSP | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| M3K1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| M3K1_HUMAN do not have mutation site. |
| Differential expressed protein |
| M3K1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| M3K1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| M4K3_HUMAN | M3K1_HUMAN | kinase -> substrate | KEGG |
| M3K1_HUMAN | IKKA_HUMAN | kinase -> substrate | KEGG |
| M3K1_HUMAN | MP2K7_HUMAN | kinase -> substrate | RegPhos |
| M3K1_HUMAN | MP2K4_HUMAN | kinase -> substrate | KEGG |
| RIPK1_HUMAN | M3K1_HUMAN | kinase -> substrate | NetPath |
| M3K1_HUMAN | MP2K1_HUMAN | kinase -> substrate | KEGG |
| M4K4_HUMAN | M3K1_HUMAN | kinase -> substrate | KEGG |
| M3K1_HUMAN | IKBA_HUMAN | kinase -> substrate | NetPath |
| M3K1_HUMAN | MP2K2_HUMAN | kinase -> substrate | KEGG |
| M3K1_HUMAN | M3K1_HUMAN | kinase -> substrate | NetPath |
| DTX1_HUMAN | M3K1_HUMAN | ubiquitination | NetPath |
| CDC42_HUMAN | M3K1_HUMAN | other | KEGG |
| RAC1_HUMAN | M3K1_HUMAN | other | KEGG |
| TRAF2_HUMAN | M3K1_HUMAN | other | KEGG |
| CASP3_HUMAN | M3K1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04912 | GnRH signaling pathway |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007179 | transforming growth factor beta receptor signaling | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0000186 | activation of MAPKK activity | NAS | biological_process |
| GO:0002224 | toll-like receptor signaling pathway | TAS | biological_process |
| GO:0008545 | JUN kinase kinase activity | IEA | molecular_function |
| GO:0043010 | camera-type eye development | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0007254 | JNK cascade | IEA | biological_process |
| GO:0030334 | regulation of cell migration | IEA | biological_process |
| GO:0071260 | cellular response to mechanical stimulus | IEP | biological_process |
| GO:0006468 | protein phosphorylation | NAS | biological_process |
| GO:0034142 | toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0042060 | wound healing | IEA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | NAS | molecular_function |
| GO:0008063 | Toll signaling pathway | TAS | biological_process |
| GO:0034130 | toll-like receptor 1 signaling pathway | TAS | biological_process |
| GO:0007257 | activation of JUN kinase activity | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008637 | apoptotic mitochondrial changes | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0034134 | toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0030838 | positive regulation of actin filament polymerizati | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathw | TAS | biological_process |