| UniProt/SwissProt ID: | PTN13_HUMAN |
| Description: | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) [Source:HGNC Symbol;Acc:9646] |
| Location: | chr4 q21.3 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1824 | QDPAKsDGRLK | PDZ | PhosphoSitePlus |
| S2383 | DHDTPsQPDDL | HPRD | |
| S897 | NLQAEsVRGFN | PhosphoSitePlus | |
| S1024 | TKLNNsKSVAS | PhosphoSitePlus | |
| S911 | AISTGsLASST | PhosphoSitePlus; HPRD | |
| S895 | WSIVSsPEREI | HPRD | |
| S240 | KGLSKsMGFLS | PhosphoSitePlus | |
| T508 | LYPGDtIKASM | PhosphoSitePlus | |
| Y2249 | KNILPyDATRV | Y_phosphatase | PhosphoSitePlus |
| S1358 | FKTFSsSPPKP | PhosphoSitePlus | |
| T335 | TVRTStTPRKK | PhosphoSitePlus | |
| S130 | GDHLNsILLGM | PhosphoSitePlus | |
| S890 | RASFRsLNLQA | PhosphoSitePlus; HPRD | |
| S2364 | DHDTPsQPDDL | HPRD | |
| S1514 | SGLGFsFSRED | PDZ | PhosphoSitePlus |
| S214 | LPTGRsSTSDV | PhosphoSitePlus | |
| S1495 | SGLGFsFSRED | HPRD | |
| S1187 | ISKVPsTPVHL | PhosphoSitePlus | |
| S938 | KRLSCsELSLY | PhosphoSitePlus | |
| S1067 | WSIVSsPEREI | HPRD | |
| Y2375 | LTFISyMRHIH | HPRD | |
| S1026 | LNNSKsVASLN | PhosphoSitePlus | |
| S2398 | LLTFIsYMRHI | HPRD | |
| S1519 | SGLGFsFSRED | HPRD | |
| S1566 | SLKGLsQQEVI | PDZ | PhosphoSitePlus |
| S442 | SKRFEsSSGLP | PhosphoSitePlus | |
| S2393 | LLTFIsYMRHI | HPRD | |
| S2202 | LLTFIsYMRHI | HPRD | |
| S2374 | LLTFIsYMRHI | HPRD | |
| Y504 | SRLSLyPGDTI | PhosphoSitePlus | |
| S2032 | YQIKGsPNLTL | PhosphoSitePlus | |
| S2192 | DHDTPsQPDDL | HPRD | |
| T1577 | SALRGtAPEVF | PDZ | PhosphoSitePlus |
| S1610 | VEQSTsSDENE | HPRD | |
| S1029 | SKSVAsLNRSP | PhosphoSitePlus | |
| S1343 | KQESSsSVNTS | PhosphoSitePlus | |
| S1086 | WSIVSsPEREI | PhosphoSitePlus; HPRD | |
| S839 | TLQNTsDGIKH | FERM_C | PhosphoSitePlus |
| S502 | RQSRLsLYPGD | PhosphoSitePlus | |
| Y943 | SELSLyQPLQN | PhosphoSitePlus | |
| S829 | KKISFsKKKIT | FERM_C | PhosphoSitePlus |
| T838 | ITLQNtSDGIK | FERM_C | PhosphoSitePlus |
| S2388 | DHDTPsQPDDL | HPRD | |
| Y2394 | LTFISyMRHIH | HPRD | |
| T528 | EIALEtAMTQR | PhosphoSitePlus | |
| S914 | TGSLAsSTLNK | PhosphoSitePlus | |
| S1033 | ASLNRsPERRK | PhosphoSitePlus | |
| S1041 | RRKHEsDSSSI | PhosphoSitePlus | |
| S1438 | VEQSTsSDENE | HPRD | |
| S908 | MGRAIsTGSLA | PhosphoSitePlus; HPRD | |
| Y2399 | LTFISyMRHIH | HPRD | |
| S345 | KEARYsDGSIA | PhosphoSitePlus | |
| S1082 | LHKRWsIVSSP | PhosphoSitePlus; phosphoELM | |
| S969 | REMSKsYHDLS | PhosphoSitePlus | |
| S915 | GSLASsTLNKL | PhosphoSitePlus | |
| T1355 | KMNFKtFSSSP | PhosphoSitePlus | |
| T1188 | SKVPStPVHLT | PhosphoSitePlus | |
| S1323 | SGLGFsFSRED | HPRD | |
| S1634 | VEQSTsSDENE | HPRD | |
| T909 | GRAIStGSLAS | PhosphoSitePlus | |
| T916 | SLASStLNKLA | PhosphoSitePlus | |
| Y2203 | LTFISyMRHIH | HPRD | |
| S936 | ILKRLsCSELS | PhosphoSitePlus | |
| S1629 | VEQSTsSDENE | HPRD | |
| S1514 | SGLGFsFSRED | HPRD | |
| Dephosphorylation site |
| PTN13_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000394794 | A880G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000394794 | T673I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000394794 | T838I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000408368 | Q1693E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | N1525S | COSMIC | Melanoma | 19074898 | ENSP00000394794 | S1754L | COSMIC | Melanoma | 19074898 | ENSP00000408368 | D2416N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | T2422N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000394794 | T2422N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000407249 | Q1712E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | I1527M | COSMIC | Melanoma | 19074898 | ENSP00000407249 | Q2228H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000394794 | N1525S | COSMIC | Melanoma | 19074898 | ENSP00000408368 | I2373T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000394794 | I1175M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000426626 | Q2233H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | T673I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000426626 | S1754L | COSMIC | Melanoma | 19074898 | ENSP00000322675 | Q1521E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000394794 | Q2467L | COSMIC | Melanoma | 19074898 | ENSP00000426626 | I1175M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000408368 | T673I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000407249 | D2435N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000408368 | Q2209H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | D2440N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000394794 | Q1717E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000394794 | R1522* | COSMIC | Melanoma | 19074898 | ENSP00000322675 | D2244N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | Q1717E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000322675 | Q2037H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000408368 | T2398N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000426626 | R1522* | COSMIC | Melanoma | 19074898 | ENSP00000394794 | I1527M | COSMIC | Melanoma | 19074898 | ENSP00000426626 | Q2467L | COSMIC | Melanoma | 19074898 | ENSP00000426626 | I2373T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000394794 | D2440N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000394794 | I2373T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000394794 | Q2233H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000426626 | A880G | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| PTN13_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTN13_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN13_HUMAN | IKBA_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PTN13_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0030027 | lamellipodium | IDA | cellular_component |
| GO:0004725 | protein tyrosine phosphatase activity | IDA | molecular_function |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |