Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K13_HUMAN
Description:mitogen-activated protein kinase kinase kinase 13 [Source:HGNC Symbol;Acc:6852]
Location:chr3 q27.2
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S811RPLQKsGDDSSPhosphoSitePlus
S789CRSESsLGTSHPhosphoSitePlus
T288PNVLVtHTDAVPkinase_TyrPhosphoSitePlus
S282HRDLKsPNVLVPkinase_TyrPhosphoSitePlus
S579KMSTSsSKSRYPhosphoSitePlus
S567VAPTAsPLSGSPhosphoSitePlus
S578PKMSTsSSKSRPhosphoSitePlus
Y483RANNLyMELSAIFT57PhosphoSitePlus
Y511AVEKKyPGTYKPhosphoSitePlus

Dephosphorylation site
M3K13_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000399910R521HTCGAOvarian Cancer21720365, 18772890
ENSP00000265026R521HTCGAOvarian Cancer21720365, 18772890
ENSP00000265026R459IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000399910V317FTCGAOvarian Cancer21720365, 18772890
ENSP00000265026V317FTCGAOvarian Cancer21720365, 18772890
ENSP00000411483R252IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000399910R459IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265026P746LGreenman2007Skin Cancer17344846, 18428421
ENSP00000409325R315IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000265026P373SBIOMARTBreast Cancer21930507, 21930502
ENSP00000399910P373SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
M3K13_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K13_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K13_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
M3K13_HUMANZN397_HUMANkinase -> substrateRobert H Newman (2013)
M3K13_HUMANMP2K7_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
M3K13_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
M3K13_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0004709MAP kinase kinase kinase activityIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0007254JNK cascadeIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016020membraneIDAcellular_component
GO:0019901protein kinase bindingISSmolecular_function
GO:0000186activation of MAPKK activityIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0008385IkappaB kinase complexIDAcellular_component


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