Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLK1_HUMAN
Description:tousled-like kinase 1 [Source:HGNC Symbol;Acc:11841]
Location:chr2 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S744RRSNSsGNLHMHPRD
T179SHSHStPSSSVHPRD; RegPhos
S741PHMRRsNSSGNHPRD
S743MRRSNsSGNLHCHK1phosphoELM; RegPhos
S743MRRSNsSGNLHRegPhos
S158QGGNGsSPVRGHPRD
S133ENQNEsSQGKSPhosphoSitePlus
S138SSQGKsIGGRGPhosphoSitePlus
S159GGNGSsPVRGIHPRD; phosphoELM; RegPhos; SysPTM
S743MRRSNsSGNLHCHEK1HPRD
S190RPNSPsPTALAHPRD; RegPhos

Dephosphorylation site
TLK1_HUMAN do not have dephosphorylation site.

Mutation site
TLK1_HUMAN do not have mutation site.

Differential expressed protein
TLK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTLK1_HUMANkinase -> substrateRegPhos
CHK1_HUMANTLK1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
TLK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007049cell cycleIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0006886intracellular protein transportIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016568chromatin modificationIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0035556intracellular signal transductionIDAbiological_process
GO:0001672regulation of chromatin assembly or disassemblyIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function


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