| UniProt/SwissProt ID: | MK13_HUMAN |
| Description: | mitogen-activated protein kinase 13 [Source:HGNC Symbol;Acc:6875] |
| Location: | chr6 p21.31 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y10 | RKKGFyKQDVN | PhosphoSitePlus | |
| T180 | ADAEMtGYVVT | Pkinase | PhosphoSitePlus |
| S47 | AIDKRsGEKVA | HPRD; phosphoELM; SysPTM | |
| Y182 | AEMTGyVVTRW | HPRD; phosphoELM; RegPhos | |
| T180 | ADAEMtGYVVT | MAP2K6 | HPRD; RegPhos |
| Y182 | AEMTGyVVTRW | Pkinase | PhosphoSitePlus |
| T185 | TGYVVtRWYRA | Pkinase | PhosphoSitePlus |
| S350 | EIVNFsPIARK | PhosphoSitePlus | |
| S357 | IARKDsRRRSG | PhosphoSitePlus | |
| S361 | DSRRRsGMKL_ | PhosphoSitePlus | |
| S47 | AIDKRsGEKVA | Pkinase | PhosphoSitePlus; SysPTM |
| T180 | ADAEMtGYVVT | RegPhos | |
| Dephosphorylation site |
| MK13_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000211287 | E316* | Greenman2007 | Breast Cancer | 15908952, 17344846, 18428421 | ENSP00000211287 | E316X | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000211287 | V184M | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000211287 | Uterine Cancer | Treatment(none vs. 5-Fluorouracil treatment) | cell line | Up | 15585135 | |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y182 | Pkinase | ADAEMTGyVVTRWYR | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK13_HUMAN | KPCA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K6_HUMAN | MK13_HUMAN | kinase -> substrate | HPRD; RegPhos |
| MK13_HUMAN | MAX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK13_HUMAN | CLK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK13_HUMAN | STMN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | MK13_HUMAN | kinase -> substrate | RegPhos |
| MK13_HUMAN | CHK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK13_HUMAN | EF2K_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05152 | Tuberculosis |
| hsa04380 | Osteoclast differentiation |
| hsa05133 | Pertussis |
| hsa04660 | T cell receptor signaling pathway |
| hsa05160 | Hepatitis C |
| hsa04728 | Dopaminergic synapse |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa04912 | GnRH signaling pathway |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04722 | Neurotrophin signaling pathway |
| hsa05140 | Leishmaniasis |
| hsa04370 | VEGF signaling pathway |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa05164 | Influenza A |
| hsa05131 | Shigellosis |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa05169 | Epstein-Barr virus infection |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa05132 | Salmonella infection |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04010 | MAPK signaling pathway |
| hsa05145 | Toxoplasmosis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0050729 | positive regulation of inflammatory response | IC | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0006950 | response to stress | IDA | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007243 | intracellular protein kinase cascade | IDA | biological_process |
| GO:0006970 | response to osmotic stress | IDA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0032755 | positive regulation of interleukin-6 production | IMP | biological_process |
| GO:0004707 | MAP kinase activity | IDA | molecular_function |