Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK13_HUMAN
Description:mitogen-activated protein kinase 13 [Source:HGNC Symbol;Acc:6875]
Location:chr6 p21.31
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y10RKKGFyKQDVNPhosphoSitePlus
T180ADAEMtGYVVTPkinasePhosphoSitePlus
S47AIDKRsGEKVAHPRD; phosphoELM; SysPTM
Y182AEMTGyVVTRWHPRD; phosphoELM; RegPhos
T180ADAEMtGYVVTMAP2K6HPRD; RegPhos
Y182AEMTGyVVTRWPkinasePhosphoSitePlus
T185TGYVVtRWYRAPkinasePhosphoSitePlus
S350EIVNFsPIARKPhosphoSitePlus
S357IARKDsRRRSGPhosphoSitePlus
S361DSRRRsGMKL_PhosphoSitePlus
S47AIDKRsGEKVAPkinasePhosphoSitePlus; SysPTM
T180ADAEMtGYVVTRegPhos

Dephosphorylation site
MK13_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000211287E316*Greenman2007Breast Cancer15908952, 17344846, 18428421
ENSP00000211287E316XBIOMARTBreast Cancer21930507, 21930502
ENSP00000211287V184MTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000211287Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineUp15585135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y182PkinaseADAEMTGyVVTRWYRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK13_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
MP2K6_HUMANMK13_HUMANkinase -> substrateHPRD; RegPhos
MK13_HUMANMAX_HUMANkinase -> substrateRobert H Newman (2013)
MK13_HUMANCLK1_HUMANkinase -> substrateRobert H Newman (2013)
MK13_HUMANSTMN1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMK13_HUMANkinase -> substrateRegPhos
MK13_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
MK13_HUMANEF2K_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis
hsa04380Osteoclast differentiation
hsa05133Pertussis
hsa04660T cell receptor signaling pathway
hsa05160Hepatitis C
hsa04728Dopaminergic synapse
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04622RIG-I-like receptor signaling pathway
hsa04912GnRH signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa05140Leishmaniasis
hsa04370VEGF signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05164Influenza A
hsa05131Shigellosis
hsa04621NOD-like receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa04664Fc epsilon RI signaling pathway
hsa05132Salmonella infection
hsa04914Progesterone-mediated oocyte maturation
hsa04620Toll-like receptor signaling pathway
hsa04010MAPK signaling pathway
hsa05145Toxoplasmosis
hsa05142Chagas disease (American trypanosomiasis)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000165MAPK cascadeIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006950response to stressIDAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0006970response to osmotic stressIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0032755positive regulation of interleukin-6 productionIMPbiological_process
GO:0004707MAP kinase activityIDAmolecular_function


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