Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CLSPN_HUMAN
Description:claspin [Source:HGNC Symbol;Acc:19715]
Location:chr1 p34.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T987SGSFPtDKEEEPhosphoSitePlus
S65KVLQDsDSETEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S714AVGFLsVPKSLPhosphoSitePlus
T916LLDLCtGKFTSCHEK1HPRD
S1018DEDEHsDSGNDPhosphoSitePlus; HPRD; phosphoELM
Y843DSQDLyNASPEPhosphoSitePlus; HPRD
S1204EIGEDsQFMILPhosphoSitePlus
S703ENNDGsSEIGKPhosphoSitePlus
Y93NKENLyAGKNTPhosphoSitePlus; HPRD
S83KTTYDsAEEENPhosphoSitePlus; HPRD; phosphoELM
S1020DEHSDsGNDLAPhosphoSitePlus; HPRD; phosphoELM
S846DLYNAsPEPKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1289VFHTLsPVKAEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T955SQDAStPASSEPhosphoSitePlus; HPRD
T1287NFVFHtLSPVKHPRD; phosphoELM; RegPhos
S720VPKSLsSDSTLPhosphoSitePlus; HPRD; phosphoELM
T949CSGKFtSQDASPhosphoSitePlus
Y306ALNLPyHMPENPhosphoSitePlus
S958ASTPAsSELNKPhosphoSitePlus; HPRD; phosphoELM
S67LQDSDsETEDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y887NHRNQyQALKPPhosphoSitePlus
T1322PKHLKtDDSTSPhosphoSitePlus
T1161SDDDQtEEQLDPhosphoSitePlus; HPRD; phosphoELM
T802TSFFPtAGGFRHPRD
S950SGKFTsQDASTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S959STPASsELNKQHPRD
S762LDEDDsCSLLTHPRD; RegPhos
S810GFRSPsPGLFRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S75EDTNAsPEKTTHPRD; RegPhos
S1223LQKNAsRPMVIPhosphoSitePlus
S721PKSLSsDSTLLPhosphoSitePlus
S833KLSEPsLPIEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S516GADEDsFVILEHPRD
S34DSGQGsYETIGPhosphoSitePlus
S839LPIEDsQDLYNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1310KKRGPsFMTSPPhosphoSitePlus
T916LLDLCtGKFTSPhosphoSitePlus
S1147NIDDAsQMDLFPhosphoSitePlus; HPRD
S393QIITGsDESCRHPRD
S718LSVPKsLSSDSPhosphoSitePlus; HPRD
S1316FMTSPsPKHLKPhosphoSitePlus
S945LLNLCsGKFTSPhosphoSitePlus
T724LSSDStLLLFKPhosphoSitePlus; HPRD; phosphoELM
S954TSQDAsTPASSPhosphoSitePlus; HPRD; phosphoELM
T69DSDSEtEDTNAHPRD; phosphoELM
S1012DNEFDsDEDEHPhosphoSitePlus; HPRD; phosphoELM
S808AGGFRsPSPGLPhosphoSitePlus; HPRD; phosphoELM
S775SSHNSsFELIGHPRD; phosphoELM
S1156LFHRDsDDDQTPhosphoSitePlus; HPRD; phosphoELM
S225EDENNsPLEDEPhosphoSitePlus; HPRD; phosphoELM
S30DSPSDsGQGSYPhosphoSitePlus
S723SLSSDsTLLLFPhosphoSitePlus; HPRD
T916LLDLCtGKFTSCHK1RegPhos
S764EDDSCsLLTKEHPRD; RegPhos
S704NNDGSsEIGKAPhosphoSitePlus

Dephosphorylation site
CLSPN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000312995R491WCOSMICCentral Nervous System Neoplasms18772396
ENSP00000312995H439RSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000312995R1331QCOSMICOvarian Cancer21720365
ENSP00000312995E441*COSMICLung Cancer
ENSP00000312995E672*BIOMARTBreast Cancer21930507, 21930502
ENSP00000251195E672*BIOMARTBreast Cancer21930507, 21930502
ENSP00000362317E608*BIOMARTBreast Cancer21930507, 21930502
ENSP00000312995L456VCOSMICOvarian Cancer21720365
ENSP00000312995N437TCOSMICRenal Cancer20054297

Differential expressed protein
CLSPN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CLSPN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CHK1_HUMANCLSPN_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANCLSPN_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
CLSPN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006915apoptotic processTASbiological_process
GO:0033314mitotic cell cycle DNA replication checkpointIMPbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000075cell cycle checkpointTASbiological_process
GO:0031572G2/M transition DNA damage checkpointIDAbiological_process
GO:0000077DNA damage checkpointIMPbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0032147activation of protein kinase activityIDAbiological_process
GO:0006281DNA repairIEAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0010997anaphase-promoting complex bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0006921cellular component disassembly involved in executiTASbiological_process


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