| UniProt/SwissProt ID: | CLSPN_HUMAN |
| Description: | claspin [Source:HGNC Symbol;Acc:19715] |
| Location: | chr1 p34.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T987 | SGSFPtDKEEE | PhosphoSitePlus | |
| S65 | KVLQDsDSETE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S714 | AVGFLsVPKSL | PhosphoSitePlus | |
| T916 | LLDLCtGKFTS | CHEK1 | HPRD |
| S1018 | DEDEHsDSGND | PhosphoSitePlus; HPRD; phosphoELM | |
| Y843 | DSQDLyNASPE | PhosphoSitePlus; HPRD | |
| S1204 | EIGEDsQFMIL | PhosphoSitePlus | |
| S703 | ENNDGsSEIGK | PhosphoSitePlus | |
| Y93 | NKENLyAGKNT | PhosphoSitePlus; HPRD | |
| S83 | KTTYDsAEEEN | PhosphoSitePlus; HPRD; phosphoELM | |
| S1020 | DEHSDsGNDLA | PhosphoSitePlus; HPRD; phosphoELM | |
| S846 | DLYNAsPEPKT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S1289 | VFHTLsPVKAE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T955 | SQDAStPASSE | PhosphoSitePlus; HPRD | |
| T1287 | NFVFHtLSPVK | HPRD; phosphoELM; RegPhos | |
| S720 | VPKSLsSDSTL | PhosphoSitePlus; HPRD; phosphoELM | |
| T949 | CSGKFtSQDAS | PhosphoSitePlus | |
| Y306 | ALNLPyHMPEN | PhosphoSitePlus | |
| S958 | ASTPAsSELNK | PhosphoSitePlus; HPRD; phosphoELM | |
| S67 | LQDSDsETEDT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y887 | NHRNQyQALKP | PhosphoSitePlus | |
| T1322 | PKHLKtDDSTS | PhosphoSitePlus | |
| T1161 | SDDDQtEEQLD | PhosphoSitePlus; HPRD; phosphoELM | |
| T802 | TSFFPtAGGFR | HPRD | |
| S950 | SGKFTsQDAST | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S959 | STPASsELNKQ | HPRD | |
| S762 | LDEDDsCSLLT | HPRD; RegPhos | |
| S810 | GFRSPsPGLFR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S75 | EDTNAsPEKTT | HPRD; RegPhos | |
| S1223 | LQKNAsRPMVI | PhosphoSitePlus | |
| S721 | PKSLSsDSTLL | PhosphoSitePlus | |
| S833 | KLSEPsLPIED | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S516 | GADEDsFVILE | HPRD | |
| S34 | DSGQGsYETIG | PhosphoSitePlus | |
| S839 | LPIEDsQDLYN | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S1310 | KKRGPsFMTSP | PhosphoSitePlus | |
| T916 | LLDLCtGKFTS | PhosphoSitePlus | |
| S1147 | NIDDAsQMDLF | PhosphoSitePlus; HPRD | |
| S393 | QIITGsDESCR | HPRD | |
| S718 | LSVPKsLSSDS | PhosphoSitePlus; HPRD | |
| S1316 | FMTSPsPKHLK | PhosphoSitePlus | |
| S945 | LLNLCsGKFTS | PhosphoSitePlus | |
| T724 | LSSDStLLLFK | PhosphoSitePlus; HPRD; phosphoELM | |
| S954 | TSQDAsTPASS | PhosphoSitePlus; HPRD; phosphoELM | |
| T69 | DSDSEtEDTNA | HPRD; phosphoELM | |
| S1012 | DNEFDsDEDEH | PhosphoSitePlus; HPRD; phosphoELM | |
| S808 | AGGFRsPSPGL | PhosphoSitePlus; HPRD; phosphoELM | |
| S775 | SSHNSsFELIG | HPRD; phosphoELM | |
| S1156 | LFHRDsDDDQT | PhosphoSitePlus; HPRD; phosphoELM | |
| S225 | EDENNsPLEDE | PhosphoSitePlus; HPRD; phosphoELM | |
| S30 | DSPSDsGQGSY | PhosphoSitePlus | |
| S723 | SLSSDsTLLLF | PhosphoSitePlus; HPRD | |
| T916 | LLDLCtGKFTS | CHK1 | RegPhos |
| S764 | EDDSCsLLTKE | HPRD; RegPhos | |
| S704 | NNDGSsEIGKA | PhosphoSitePlus | |
| Dephosphorylation site |
| CLSPN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000312995 | R491W | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000312995 | H439R | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000312995 | R1331Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000312995 | E441* | COSMIC | Lung Cancer | ENSP00000312995 | E672* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000251195 | E672* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000362317 | E608* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000312995 | L456V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000312995 | N437T | COSMIC | Renal Cancer | 20054297 |
| Differential expressed protein |
| CLSPN_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CLSPN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CHK1_HUMAN | CLSPN_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | CLSPN_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| CLSPN_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0033314 | mitotic cell cycle DNA replication checkpoint | IMP | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0031572 | G2/M transition DNA damage checkpoint | IDA | biological_process |
| GO:0000077 | DNA damage checkpoint | IMP | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0032147 | activation of protein kinase activity | IDA | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0010997 | anaphase-promoting complex binding | IPI | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |