Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BMP2_HUMAN
Description:bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:1069]
Location:chr20 p12.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T181IIKPAtANSKFTGFb_propeptidePhosphoSitePlus
S184PATANsKFPVTTGFb_propeptidePhosphoSitePlus

Dephosphorylation site
BMP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368104I145LCOSMICOvarian Cancer21720365
ENSP00000368104G327ECOSMICBreast Cancer20668451
ENSP00000368104I145LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
BMP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BMP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMP2_HUMANBMR1A_HUMANligand -> receptorHPMR
BMP2_HUMANBMR1B_HUMANligand -> receptorHPMR
BMP2_HUMANBMPR2_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042487regulation of odontogenesis of dentin-containing tIEAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathIEAbiological_process
GO:0060128corticotropin hormone secreting cell differentiatiISSbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0009790embryo developmentISSbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0001666response to hypoxiaISSbiological_process
GO:0003203endocardial cushion morphogenesisISSbiological_process
GO:0072138mesenchymal cell proliferation involved in ureteriISSbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0060804positive regulation of Wnt receptor signaling pathIEAbiological_process
GO:0045786negative regulation of cell cycleIDAbiological_process
GO:0048711positive regulation of astrocyte differentiationISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0060039pericardium developmentISSbiological_process
GO:0042475odontogenesis of dentin-containing toothISSbiological_process
GO:0060039pericardium developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0040007growthIEAbiological_process
GO:0001501skeletal system developmentTASbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0035054embryonic heart tube anterior/posterior pattern spISSbiological_process
GO:0045600positive regulation of fat cell differentiationIEAbiological_process
GO:0031648protein destabilizationIEAbiological_process
GO:0032348negative regulation of aldosterone biosynthetic prIDAbiological_process
GO:0030335positive regulation of cell migrationISSbiological_process
GO:0055008cardiac muscle tissue morphogenesisIEAbiological_process
GO:0045778positive regulation of ossificationIDAbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0006954inflammatory responseIEAbiological_process
GO:0001649osteoblast differentiationIDAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0060128corticotropin hormone secreting cell differentiatiIEAbiological_process
GO:0045666positive regulation of neuron differentiationISSbiological_process
GO:0019211phosphatase activator activityIDAmolecular_function
GO:1901522positive regulation of transcription from RNA polyIDAbiological_process
GO:0003130BMP signaling pathway involved in heart inductionIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0035630bone mineralization involved in bone maturationIDAbiological_process
GO:0045669positive regulation of osteoblast differentiationIDAbiological_process
GO:0060129thyroid-stimulating hormone-secreting cell differeIEAbiological_process
GO:0042482positive regulation of odontogenesisIEAbiological_process
GO:0003181atrioventricular valve morphogenesisIEAbiological_process
GO:0033690positive regulation of osteoblast proliferationISSbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0045600positive regulation of fat cell differentiationISSbiological_process
GO:0055007cardiac muscle cell differentiationIMPbiological_process
GO:0051216cartilage developmentIEAbiological_process
GO:0055008cardiac muscle tissue morphogenesisISSbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisISSbiological_process
GO:0021537telencephalon developmentIDAbiological_process
GO:0021978telencephalon regionalizationISSbiological_process
GO:2000065negative regulation of cortisol biosynthetic proceIDAbiological_process
GO:0045165cell fate commitmentISSbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0006954inflammatory responseISSbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0045778positive regulation of ossificationIEAbiological_process
GO:0060389pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0009887organ morphogenesisISSbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathISSbiological_process
GO:0030282bone mineralizationIEAbiological_process
GO:0048711positive regulation of astrocyte differentiationIEAbiological_process
GO:0060804positive regulation of Wnt receptor signaling pathISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0004745retinol dehydrogenase activityIEAmolecular_function
GO:0042482positive regulation of odontogenesisISSbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0003203endocardial cushion morphogenesisIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0021978telencephalon regionalizationIEAbiological_process
GO:0030282bone mineralizationISSbiological_process
GO:0030501positive regulation of bone mineralizationIDAbiological_process
GO:0035054embryonic heart tube anterior/posterior pattern spIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0071773cellular response to BMP stimulusIDAbiological_process
GO:0061036positive regulation of cartilage developmentIEAbiological_process
GO:0048839inner ear developmentISSbiological_process
GO:0060485mesenchyme developmentIMPbiological_process
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0001701in utero embryonic developmentISSbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0004745retinol dehydrogenase activityISSmolecular_function
GO:0035051cardiocyte differentiationIDAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0060317cardiac epithelial to mesenchymal transitionIDAbiological_process
GO:0007219Notch signaling pathwayISSbiological_process
GO:0033690positive regulation of osteoblast proliferationIEAbiological_process
GO:0048762mesenchymal cell differentiationIDAbiological_process
GO:0072138mesenchymal cell proliferation involved in ureteriIEAbiological_process
GO:0001837epithelial to mesenchymal transitionIDAbiological_process
GO:0003308negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0043569negative regulation of insulin-like growth factor IDAbiological_process
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0061036positive regulation of cartilage developmentIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0070700BMP receptor bindingIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0060129thyroid-stimulating hormone-secreting cell differeISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:2000726negative regulation of cardiac muscle cell differeIDAbiological_process
GO:0046332SMAD bindingIDAmolecular_function
GO:0010922positive regulation of phosphatase activityIDAbiological_process
GO:0006029proteoglycan metabolic processIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003181atrioventricular valve morphogenesisISSbiological_process
GO:0001938positive regulation of endothelial cell proliferatIDAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIDAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0010894negative regulation of steroid biosynthetic procesIDAbiological_process