| UniProt/SwissProt ID: | BMP15_HUMAN |
| Description: | bone morphogenetic protein 15 [Source:HGNC Symbol;Acc:1068] |
| Location: | chrX p11.22 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y378 | NGSILyKEYEG | TGF_beta | PhosphoSitePlus |
| Y235 | AFLLLyFNDTH | PhosphoSitePlus | |
| S273 | QADGIsAEVTA | PhosphoSitePlus | |
| T89 | PRENRtIGATM | PhosphoSitePlus | |
| T102 | LVKPLtNVARP | PhosphoSitePlus | |
| S366 | KYVPIsVLMIE | TGF_beta | PhosphoSitePlus |
| Dephosphorylation site |
| BMP15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000252677 | L293I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000252677 | L293I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000252677 | Q210L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000252677 | Q210L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| BMP15_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BMP15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BMP15_HUMAN | BMR1B_HUMAN | ligand -> receptor | HPMR |
| BMP15_HUMAN | BMPR2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| BMP15_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0060016 | granulosa cell development | IEA | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0001541 | ovarian follicle development | IEA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007292 | female gamete generation | TAS | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |