| UniProt/SwissProt ID: | DNJB2_HUMAN |
| Description: | DnaJ (Hsp40) homolog, subfamily B, member 2 [Source:HGNC Symbol;Acc:5228] |
| Location: | chr2 q35 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y4 | EILD | HPRD | |
| S219 | LGLELsRREQQ | PhosphoSitePlus | |
| S313 | TKRSPsPEEKA | PhosphoSitePlus; SysPTM | |
| T204 | QLKSVtINGVP | PhosphoSitePlus | |
| Y261 | QLAMAySLSEM | UIM | PhosphoSitePlus |
| S15 | VPRSAsADDIK | HPRD | |
| S3 | YEIL | HPRD | |
| Y65 | HKREIyDRYGR | DnaJ | PhosphoSitePlus |
| T78 | LTGTGtGPSRA | PhosphoSitePlus | |
| S202 | DGQLKsVTING | PhosphoSitePlus | |
| T95 | PGFTFtFRSPE | PhosphoSitePlus | |
| T76 | EGLTGtGTGPS | PhosphoSitePlus | |
| T239 | TQVQQtPASCP | PhosphoSitePlus | |
| S13 | LDVPRsASADD | HPRD | |
| Dephosphorylation site |
| DNJB2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000338019 | P136L | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| DNJB2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DNJB2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ACVR1_HUMAN | DNJB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | DNJB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | DNJB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DNJB2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032436 | positive regulation of proteasomal ubiquitin-depen | IDA | biological_process |
| GO:0016234 | inclusion body | IDA | cellular_component |
| GO:0030433 | ER-associated protein catabolic process | IDA | biological_process |
| GO:0090084 | negative regulation of inclusion body assembly | IDA | biological_process |
| GO:0031072 | heat shock protein binding | IEA | molecular_function |
| GO:0031593 | polyubiquitin binding | IDA | molecular_function |
| GO:0031398 | positive regulation of protein ubiquitination | IDA | biological_process |
| GO:0030544 | Hsp70 protein binding | IPI | molecular_function |
| GO:0090086 | negative regulation of protein deubiquitination | IDA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IGI | biological_process |
| GO:0030308 | negative regulation of cell growth | IGI | biological_process |
| GO:0070628 | proteasome binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051082 | unfolded protein binding | IEA | molecular_function |
| GO:0000502 | proteasome complex | IDA | cellular_component |
| GO:0006986 | response to unfolded protein | TAS | biological_process |
| GO:0006457 | protein folding | IEA | biological_process |