Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD5R1_HUMAN
Description:cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Source:HGNC Symbol;Acc:1775]
Location:chr17 q11.2
Node attribute:PPI(source); kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T138VTSAGtPKRVIphosphoELM
S8TVLSLsPSYRKCDK5_activatorPhosphoSitePlus
S8TVLSLsPSYRKCDK5phosphoELM
S91LKKSLsCANLSphosphoELM
T138VTSAGtPKRVICDK5_activatorPhosphoSitePlus
T138VTSAGtPKRVICDK5phosphoELM
S8TVLSLsPSYRKphosphoELM

Dephosphorylation site
CD5R1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318486M206VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
CD5R1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD5R1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CD5R1_HUMANTAU_HUMANkinase -> substrateKEGG
CAN1_HUMANCD5R1_HUMANotherKEGG
CD5R1_HUMANCD5R1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa05030Cocaine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007411axon guidanceIEAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0007213G-protein coupled acetylcholine receptor signalingIEAbiological_process
GO:0021722superior olivary nucleus maturationIEAbiological_process
GO:0033136serine phosphorylation of STAT3 proteinIEAbiological_process
GO:0005509calcium ion bindingISSmolecular_function
GO:0071902positive regulation of protein serine/threonine kiIEAbiological_process
GO:0030426growth coneISScellular_component
GO:0014069postsynaptic densityISScellular_component
GO:0008283cell proliferationTASbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0070507regulation of microtubule cytoskeleton organizatioIEAbiological_process
GO:0061001regulation of dendritic spine morphogenesisISSbiological_process
GO:0007420brain developmentISSbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0030182neuron differentiationIEAbiological_process
GO:0043539protein serine/threonine kinase activator activityISSmolecular_function
GO:0016301kinase activityISSmolecular_function
GO:0007411axon guidanceISSbiological_process
GO:0030182neuron differentiationISSbiological_process
GO:0045296cadherin bindingISSmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0007213G-protein coupled acetylcholine receptor signalingISSbiological_process
GO:0016533cyclin-dependent protein kinase 5 holoenzyme complIEAcellular_component
GO:0009790embryo developmentIEAbiological_process
GO:0045296cadherin bindingIEAmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function
GO:0043197dendritic spineISScellular_component
GO:0031594neuromuscular junctionIEAcellular_component
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0032956regulation of actin cytoskeleton organizationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007413axonal fasciculationIEAbiological_process
GO:0021766hippocampus developmentIEAbiological_process
GO:0045664regulation of neuron differentiationNASbiological_process
GO:0005634nucleusISScellular_component
GO:0016534cyclin-dependent protein kinase 5 activator activiIEAmolecular_function
GO:0009790embryo developmentISSbiological_process
GO:0043025neuronal cell bodyISScellular_component
GO:0035235ionotropic glutamate receptor signaling pathwayIEAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0031594neuromuscular junctionISScellular_component
GO:0030426growth coneIEAcellular_component
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0043292contractile fiberIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0021819layer formation in cerebral cortexIEAbiological_process
GO:0007413axonal fasciculationISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0014069postsynaptic densityIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0021799cerebral cortex radially oriented cell migrationIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007158neuron cell-cell adhesionIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0061001regulation of dendritic spine morphogenesisIEAbiological_process
GO:0030425dendriteISScellular_component
GO:0030424axonISScellular_component
GO:0004693cyclin-dependent protein kinase activityIEAmolecular_function
GO:0021549cerebellum developmentIEAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0048013ephrin receptor signaling pathwayISSbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0090314positive regulation of protein targeting to membraIEAbiological_process
GO:0007158neuron cell-cell adhesionISSbiological_process
GO:0001764neuron migrationISSbiological_process
GO:0005737cytoplasmISScellular_component
GO:0007420brain developmentIEAbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0031175neuron projection developmentISSbiological_process
GO:0016020membraneISScellular_component
GO:0043525positive regulation of neuron apoptotic processISSbiological_process
GO:0043539protein serine/threonine kinase activator activityIEAmolecular_function
GO:0030425dendriteIEAcellular_component
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0035235ionotropic glutamate receptor signaling pathwayISSbiological_process
GO:0043292contractile fiberISScellular_component