| UniProt/SwissProt ID: | TTBK1_HUMAN |
| Description: | tau tubulin kinase 1 [Source:HGNC Symbol;Acc:19140] |
| Location: | chr6 p21.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1202 | PPGSAtAADLR | PhosphoSitePlus | |
| S944 | LNVMSsGGQAL | PhosphoSitePlus | |
| S943 | HLNVMsSGGQA | PhosphoSitePlus | |
| T1152 | GRAAAtRSRIP | PhosphoSitePlus | |
| Y169 | RLPSTyRKCYM | Pkinase_CK1 | PhosphoSitePlus |
| S1200 | QTPPGsATAAD | PhosphoSitePlus | |
| Y695 | RDLSDyRERAR | PhosphoSitePlus | |
| S1248 | RNASAsPRSQS | PhosphoSitePlus | |
| T629 | DGRSEtSQPPT | PhosphoSitePlus | |
| S790 | RSGSSsEGSER | PhosphoSitePlus | |
| T12 | ALKDEtNMSGG | Pkinase_CK1 | PhosphoSitePlus |
| S1259 | LSRREsPSPSH | PhosphoSitePlus | |
| S627 | QGDGRsETSQP | PhosphoSitePlus | |
| S1246 | AARNAsASPRS | PhosphoSitePlus | |
| S1253 | SPRSQsLSRRE | PhosphoSitePlus | |
| S693 | FKRDLsDYRER | PhosphoSitePlus | |
| S630 | GRSETsQPPTP | PhosphoSitePlus | |
| Dephosphorylation site |
| TTBK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000259750 | P855S | BIOMART | Melanoma | 21930507, 21930502 | ENSP00000259750 | P386S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000259750 | P855S | Greenman2007 | Skin Cancer | 17344846, 18428421, 21930507, 21930502 | ENSP00000259750 | S806F | HPI | Non-small cell lung carcinoma | 17344846 | ENSP00000259750 | T1065R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000259750 | S806F | Greenman2007 | Lung Cancer | 16140923, 17344846, 18428421 |
| Differential expressed protein |
| TTBK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TTBK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TTBK1_HUMAN | TAU_HUMAN | kinase -> substrate | RegPhos |
| TTBK1_HUMAN | TBB5_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| TTBK1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0030054 | cell junction | IDA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |