| UniProt/SwissProt ID: | ARHG6_HUMAN |
| Description: | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [Source:HGNC Symbol;Acc:685] |
| Location: | chrX q26.3 |
| Node attribute: | PPI(target); PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S649 | YVIRKsTAALE | PhosphoSitePlus; HPRD | |
| T635 | LHKRKtERKPS | PhosphoSitePlus | |
| S126 | RSSSLsAANTS | PhosphoSitePlus; HPRD | |
| S640 | TERKPsEEEYV | PhosphoSitePlus; HPRD | |
| S123 | PCGRSsSLSAA | PhosphoSitePlus; HPRD | |
| S592 | KPWSLsCLRPA | PhosphoSitePlus; HPRD | |
| S122 | RPCGRsSSLSA | PhosphoSitePlus; HPRD | |
| S488 | ASPRMsGFIYQ | PH | PhosphoSitePlus |
| S225 | SERPLsPKAVK | PhosphoSitePlus; HPRD; phosphoELM | |
| Y91 | DPDDLySGVNF | CH | PhosphoSitePlus |
| S669 | EAYCTsANFQQ | PhosphoSitePlus | |
| Y188 | KGDIIyVTRVE | SH3_2 | PhosphoSitePlus |
| T650 | VIRKStAALEE | HPRD | |
| Y470 | EKEERyLMLFS | HPRD | |
| S684 | STRKDsIPQVL | PhosphoSitePlus; HPRD; phosphoELM | |
| S482 | VLIMLsASPRM | HPRD | |
| T701 | LIIEEtRSNGQ | PhosphoSitePlus | |
| S622 | KESSKsPKTMK | PhosphoSitePlus | |
| T133 | ANTSQtNPQGA | PhosphoSitePlus | |
| T573 | SSFSStGQPRG | PhosphoSitePlus | |
| T717 | KSLVDtVYALK | Nsp1_C | PhosphoSitePlus |
| T504 | AGTVVtRLDEI | PH | PhosphoSitePlus |
| S124 | CGRSSsLSAAN | PhosphoSitePlus; HPRD | |
| S144 | VSSTVsGLQRQ | PhosphoSitePlus | |
| Y719 | LVDTVyALKDE | Nsp1_C | PhosphoSitePlus |
| S562 | SKTSSsSCSAH | PhosphoSitePlus | |
| S484 | IMLSAsPRMSG | HPRD | |
| Y644 | PSEEEyVIRKS | PhosphoSitePlus | |
| S488 | ASPRMsGFIYQ | HPRD; phosphoELM | |
| Y666 | KVIEAyCTSAN | PhosphoSitePlus | |
| S454 | NVIFMsQVMVQ | HPRD | |
| S150 | GLQRQsKTVEM | PhosphoSitePlus; HPRD | |
| Y614 | KERMSyILKES | PhosphoSitePlus | |
| S703 | IEETRsNGQTI | PhosphoSitePlus | |
| Dephosphorylation site |
| ARHG6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ARHG6_HUMAN do not have mutation site. |
| Differential expressed protein |
| ARHG6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ARHG6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RRAS2_HUMAN | ARHG6_HUMAN | other | KEGG |
| ARHG6_HUMAN | RAC1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05212 | Pancreatic cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030027 | lamellipodium | ISS | cellular_component |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | NAS | molecular_function |
| GO:0043547 | positive regulation of GTPase activity | NAS | biological_process |
| GO:0005096 | GTPase activator activity | NAS | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0030032 | lamellipodium assembly | IEA | biological_process |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0006915 | apoptotic process | NAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005622 | intracellular | IC | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0030032 | lamellipodium assembly | ISS | biological_process |
| GO:0034329 | cell junction assembly | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007254 | JNK cascade | NAS | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0030027 | lamellipodium | IEA | cellular_component |