Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TLR2_HUMAN
Description:toll-like receptor 2 [Source:HGNC Symbol;Acc:11848]
Location:chr4 q31.3
Node attribute:PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S48LNSIPsGLTEAPhosphoSitePlus
S143TLGETsLFSHLLRR_4PhosphoSitePlus
T262RNVKItDESLFPhosphoSitePlus
S45SGSLNsIPSGLPhosphoSitePlus
T142KTLGEtSLFSHLRR_4PhosphoSitePlus
Y653SERDAyWVENLTIRPhosphoSitePlus
T138GNPYKtLGETSLRR_4PhosphoSitePlus

Dephosphorylation site
TLR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260010S720FCOSMICSkin Cancer21984974
ENSP00000260010S223FCOSMICBreast Cancer20668451
ENSP00000260010Q390RCOSMICLung Cancer20668451
ENSP00000260010R230*BIOMARTBrain Cancer21930507, 21930502

Differential expressed protein
TLR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TLR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TLR2_HUMANRAC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04145Phagosome
hsa05152Tuberculosis
hsa05146Amoebiasis
hsa05162Measles
hsa05144Malaria
hsa05323Rheumatoid arthritis
hsa04620Toll-like receptor signaling pathway
hsa05168Herpes simplex infection
hsa05140Leishmaniasis
hsa05134Legionellosis
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009986cell surfaceIDAcellular_component
GO:0032494response to peptidoglycanIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0006955immune responseTASbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0042346positive regulation of NF-kappaB import into nucleIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071221cellular response to bacterial lipopeptideIEAbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0042497triacyl lipopeptide bindingIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0002687positive regulation of leukocyte migrationIEAbiological_process
GO:0032735positive regulation of interleukin-12 productionISSbiological_process
GO:0044130negative regulation of growth of symbiont in hostIEAbiological_process
GO:0042497triacyl lipopeptide bindingIEAmolecular_function
GO:0032695negative regulation of interleukin-12 productionIEAbiological_process
GO:0042496detection of diacyl bacterial lipopeptideIDAbiological_process
GO:0071221cellular response to bacterial lipopeptideTASbiological_process
GO:0051637Gram-positive bacterial cell surface bindingIDAmolecular_function
GO:0071223cellular response to lipoteichoic acidIDAbiological_process
GO:0071727cellular response to triacyl bacterial lipopeptideIDAbiological_process
GO:0032728positive regulation of interferon-beta productionISSbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0002752cell surface pattern recognition receptor signalinIEAbiological_process
GO:0035354Toll-like receptor 1-Toll-like receptor 2 protein IDAcellular_component
GO:0034123positive regulation of toll-like receptor signalinIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0071726cellular response to diacyl bacterial lipopeptideIDAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0032722positive regulation of chemokine productionIDAbiological_process
GO:0042498diacyl lipopeptide bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0035355Toll-like receptor 2-Toll-like receptor 6 protein IEAcellular_component
GO:0032760positive regulation of tumor necrosis factor produISSbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayTASbiological_process
GO:0051770positive regulation of nitric-oxide synthase biosyISSbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathIMPbiological_process
GO:0004872receptor activityIDAmolecular_function
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0042535positive regulation of tumor necrosis factor biosyIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0032755positive regulation of interleukin-6 productionIDAbiological_process
GO:0042495detection of triacyl bacterial lipopeptideIDAbiological_process
GO:0032700negative regulation of interleukin-17 productionIEAbiological_process
GO:0070891lipoteichoic acid bindingIEAmolecular_function
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwIEAbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0002238response to molecule of fungal originIEAbiological_process
GO:0052063induction by symbiont of defense-related host nitrIEAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0008329pattern recognition receptor activityIDAmolecular_function
GO:0042892chloramphenicol transportIEAbiological_process
GO:0071224cellular response to peptidoglycanIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0001875lipopolysaccharide receptor activityTASmolecular_function
GO:0050729positive regulation of inflammatory responseICbiological_process
GO:0042834peptidoglycan bindingIDAmolecular_function
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0032757positive regulation of interleukin-8 productionIDAbiological_process
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0032741positive regulation of interleukin-18 productionISSbiological_process
GO:0032722positive regulation of chemokine productionIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0060907positive regulation of macrophage cytokine productIEAbiological_process
GO:0050830defense response to Gram-positive bacteriumIEAbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0071223cellular response to lipoteichoic acidIEAbiological_process