| UniProt/SwissProt ID: | ARHG7_HUMAN |
| Description: | Rho guanine nucleotide exchange factor (GEF) 7 [Source:HGNC Symbol;Acc:15607] |
| Location: | chr13 q34 |
| Node attribute: | substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S763 | RRSSLsRLEPS | PhosphoSitePlus | |
| T528 | QGKLPtTGMTI | PH | PhosphoSitePlus |
| S518 | ASPRMsGFIYQ | PH | PhosphoSitePlus |
| T526 | ASRKStAALEE | HPRD | |
| S800 | CCSYIsHQN__ | PhosphoSitePlus | |
| Y427 | RHMEDyHTDRQ | RhoGEF | PhosphoSitePlus |
| Y620 | PLTPAyHTLPH | PhosphoSitePlus | |
| T580 | KQTKVtSVGNP | PhosphoSitePlus | |
| S761 | LGRRSsLSRLE | PhosphoSitePlus | |
| T233 | SPKSGtLKSPP | HPRD | |
| T722 | IEAYCtSAKTR | PhosphoSitePlus | |
| S153 | SHRIKsFDSLG | PhosphoSitePlus | |
| S740 | LGRRSsLSRLE | HPRD | |
| S694 | PERKPsDEEFA | PhosphoSitePlus; phosphoELM | |
| Y785 | WTAHSyRMGST | PhosphoSitePlus | |
| S79 | SGTLKsPPKGF | HPRD | |
| S579 | VEETKsNGQTV | HPRD | |
| S784 | IWTAHsYRMGS | PhosphoSitePlus | |
| S215 | TKGASsPGILV | HPRD | |
| T704 | ASRKStAALEE | PhosphoSitePlus | |
| S497 | ASPRMsGFIYQ | HPRD | |
| S244 | REVKAsEKPVS | PhosphoSitePlus | |
| S739 | SLGRRsSLSRL | HPRD | |
| T683 | ASRKStAALEE | HPRD | |
| S516 | PERKPsDEEFA | HPRD | |
| S539 | TKLEDsENHRN | PH | PhosphoSitePlus |
| Y595 | LVDTVyALKDE | HPRD | |
| T76 | SPKSGtLKSPP | HPRD | |
| S525 | FASRKsTAALE | HPRD | |
| S518 | ASPRMsGFIYQ | phosphoELM | |
| S653 | KPWSLsCLRPA | PhosphoSitePlus | |
| S673 | PERKPsDEEFA | HPRD | |
| S372 | TKGASsPGILV | HPRD | |
| S176 | QGQYRsLDMTD | PhosphoSitePlus | |
| S703 | FASRKsTAALE | PhosphoSitePlus | |
| S249 | SEKPVsPKSGT | PhosphoSitePlus | |
| S71 | SEKPVsPKSGT | HPRD | |
| S257 | SGTLKsPPKGF | PhosphoSitePlus | |
| Y720 | KVIEAyCTSAK | PhosphoSitePlus | |
| S682 | FASRKsTAALE | HPRD | |
| T617 | KPAPLtPAYHT | PhosphoSitePlus | |
| S236 | SGTLKsPPKGF | HPRD | |
| S340 | ASPRMsGFIYQ | HPRD | |
| S599 | SHTLPsHPVTP | PhosphoSitePlus | |
| S700 | DEEFAsRKSTA | PhosphoSitePlus | |
| S560 | SSRKEsAPQVL | HPRD | |
| S228 | SEKPVsPKSGT | HPRD | |
| T379 | GILVLtTGLSK | HPRD | |
| S723 | EAYCTsAKTRQ | PhosphoSitePlus | |
| T222 | GILVLtTGLSK | HPRD | |
| S581 | QTKVTsVGNPT | PhosphoSitePlus | |
| Dephosphorylation site |
| ARHG7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000325994 | T442M | COSMIC | Pancreatic Cancer | ENSP00000325994 | T769A | COSMIC | Renal Cancer | 21248752 | ENSP00000364893 | A614T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000397068 | T285M | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000325994 | M659R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000325994 | A593T | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000364893 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.39 | 14726492 |
| Hyperphosphorylation site |
| ARHG7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ROCK1_HUMAN | ARHG7_HUMAN | kinase -> substrate | KEGG |
| ARHG7_HUMAN | RAC1_HUMAN | other | KEGG |
| ARHG7_HUMAN | ARHGC_HUMAN | other | KEGG |
| ARHG7_HUMAN | GIT1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005938 | cell cortex | IEA | cellular_component |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0001726 | ruffle | IEA | cellular_component |
| GO:0005925 | focal adhesion | IEA | cellular_component |
| GO:0043065 | positive regulation of apoptotic process | IMP | biological_process |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0043005 | neuron projection | IDA | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0042059 | negative regulation of epidermal growth factor rec | TAS | biological_process |
| GO:0043025 | neuronal cell body | IDA | cellular_component |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0043547 | positive regulation of GTPase activity | IDA | biological_process |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030032 | lamellipodium assembly | IEA | biological_process |
| GO:0043234 | protein complex | IDA | cellular_component |