Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARHG7_HUMAN
Description:Rho guanine nucleotide exchange factor (GEF) 7 [Source:HGNC Symbol;Acc:15607]
Location:chr13 q34
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S763RRSSLsRLEPSPhosphoSitePlus
T528QGKLPtTGMTIPHPhosphoSitePlus
S518ASPRMsGFIYQPHPhosphoSitePlus
T526ASRKStAALEEHPRD
S800CCSYIsHQN__PhosphoSitePlus
Y427RHMEDyHTDRQRhoGEFPhosphoSitePlus
Y620PLTPAyHTLPHPhosphoSitePlus
T580KQTKVtSVGNPPhosphoSitePlus
S761LGRRSsLSRLEPhosphoSitePlus
T233SPKSGtLKSPPHPRD
T722IEAYCtSAKTRPhosphoSitePlus
S153SHRIKsFDSLGPhosphoSitePlus
S740LGRRSsLSRLEHPRD
S694PERKPsDEEFAPhosphoSitePlus; phosphoELM
Y785WTAHSyRMGSTPhosphoSitePlus
S79SGTLKsPPKGFHPRD
S579VEETKsNGQTVHPRD
S784IWTAHsYRMGSPhosphoSitePlus
S215TKGASsPGILVHPRD
T704ASRKStAALEEPhosphoSitePlus
S497ASPRMsGFIYQHPRD
S244REVKAsEKPVSPhosphoSitePlus
S739SLGRRsSLSRLHPRD
T683ASRKStAALEEHPRD
S516PERKPsDEEFAHPRD
S539TKLEDsENHRNPHPhosphoSitePlus
Y595LVDTVyALKDEHPRD
T76SPKSGtLKSPPHPRD
S525FASRKsTAALEHPRD
S518ASPRMsGFIYQphosphoELM
S653KPWSLsCLRPAPhosphoSitePlus
S673PERKPsDEEFAHPRD
S372TKGASsPGILVHPRD
S176QGQYRsLDMTDPhosphoSitePlus
S703FASRKsTAALEPhosphoSitePlus
S249SEKPVsPKSGTPhosphoSitePlus
S71SEKPVsPKSGTHPRD
S257SGTLKsPPKGFPhosphoSitePlus
Y720KVIEAyCTSAKPhosphoSitePlus
S682FASRKsTAALEHPRD
T617KPAPLtPAYHTPhosphoSitePlus
S236SGTLKsPPKGFHPRD
S340ASPRMsGFIYQHPRD
S599SHTLPsHPVTPPhosphoSitePlus
S700DEEFAsRKSTAPhosphoSitePlus
S560SSRKEsAPQVLHPRD
S228SEKPVsPKSGTHPRD
T379GILVLtTGLSKHPRD
S723EAYCTsAKTRQPhosphoSitePlus
T222GILVLtTGLSKHPRD
S581QTKVTsVGNPTPhosphoSitePlus

Dephosphorylation site
ARHG7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000325994T442MCOSMICPancreatic Cancer
ENSP00000325994T769ACOSMICRenal Cancer21248752
ENSP00000364893A614TTCGAOvarian Cancer21720365, 18772890
ENSP00000397068T285MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000325994M659RCOSMICOvarian Cancer21720365
ENSP00000325994A593TCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364893hepatitis B virusNormal vs. CancertissueDown0.3914726492

Hyperphosphorylation site
ARHG7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANARHG7_HUMANkinase -> substrateKEGG
ARHG7_HUMANRAC1_HUMANotherKEGG
ARHG7_HUMANARHGC_HUMANotherKEGG
ARHG7_HUMANGIT1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005938cell cortexIEAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0001726ruffleIEAcellular_component
GO:0005925focal adhesionIEAcellular_component
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0043005neuron projectionIDAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0042059negative regulation of epidermal growth factor recTASbiological_process
GO:0043025neuronal cell bodyIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005085guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0043547positive regulation of GTPase activityIDAbiological_process
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0030032lamellipodium assemblyIEAbiological_process
GO:0043234protein complexIDAcellular_component


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