Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DOCK1_HUMAN
Description:dedicator of cytokinesis 1 [Source:HGNC Symbol;Acc:2987]
Location:chr10 q26.2
Node attribute:PPI(source); PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S784INDMMsSMSDQPhosphoSitePlus
T314LRDNNtRKLTSPhosphoSitePlus
Y478EAISEyKSVIYPhosphoSitePlus
T803LKYLPtIVNDVPhosphoSitePlus
Y483YKSVIyYQVKQPhosphoSitePlus
Y1811GSVADyGNLMEPhosphoSitePlus
S1807LPLKGsVADYGPhosphoSitePlus
S1858TRKQTsVDSGIHPRD; phosphoELM; SysPTM
S265LVRWSsSGLPKPhosphoSitePlus; SysPTM
S1751MNVIGsERRFSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y800GAALKyLPTIVPhosphoSitePlus
S1842PPPLPsKTPPPPhosphoSitePlus
T1857TTRKQtSVDSGHPRD
S1743PQRPKsQVMNVPhosphoSitePlus
S319TRKLTsGLRRPPhosphoSitePlus
S1858TRKQAsVDSGIPhosphoSitePlus; SysPTM
Y107IWRQLyVQDNRPhosphoSitePlus
S204LQEEKsQKQNIPhosphoSitePlus
T1772TPPPVtPRAKLPhosphoSitePlus
T101LREWStIWRQLPhosphoSitePlus
S1758RRFSVsPSSPSPhosphoSitePlus
S818DPKELsKMFTEPhosphoSitePlus
S100TLREWsTIWRQPhosphoSitePlus

Dephosphorylation site
DOCK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000280333I65VCOSMICHead and Neck Cancer21798893
ENSP00000280333R279*TCGAOvarian Cancer21720365, 18772890
ENSP00000280333V165LCOSMICHead and Neck Cancer21798893
ENSP00000280333D436YCOSMICRenal Cancer20054297
ENSP00000280333H188YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000280333M830IBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000280333Y42CCOSMICHead and Neck Cancer21798893
ENSP00000280333E1098VCOSMICLung Cancer
ENSP00000280333Y1359CCOSMICHead and Neck Cancer21798893
ENSP00000280333V1201ICOSMICOvarian Cancer21720365
ENSP00000280333D1665YCOSMICCentral Nervous System Neoplasms18772890
ENSP00000280333K535MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000280333K535MTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000280333P1850SCOSMICBreast Cancer17932254
ENSP00000280333E843KBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000280333S1250LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000280333S1250LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000280333R279*COSMICOvarian Cancer21720365

Differential expressed protein
DOCK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DOCK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DOCK1_HUMANRAC1_HUMANotherKEGG
CRK_HUMANDOCK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05131Shigellosis
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005488bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0009055electron carrier activityIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0006911phagocytosis, engulfmentTASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0020037heme bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0043547positive regulation of GTPase activityTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016477cell migrationIEAbiological_process
GO:0005096GTPase activator activityTASmolecular_function
GO:0007229integrin-mediated signaling pathwayTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0017124SH3 domain bindingIEAmolecular_function


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