| UniProt/SwissProt ID: | ARHG4_HUMAN |
| Description: | Rho guanine nucleotide exchange factor (GEF) 4 [Source:HGNC Symbol;Acc:684] |
| Location: | chr2 q21.1 |
| Node attribute: | PPI(target); PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S280 | AEAQSsKDQMR | PhosphoSitePlus | |
| S279 | GAEAQsSKDQM | PhosphoSitePlus | |
| T286 | KDQMRtNVINE | PhosphoSitePlus | |
| Dephosphorylation site |
| ARHG4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316845 | C314Y | COSMIC | Melanoma | ENSP00000316845 | S160R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000316845 | D534N | COSMIC | Skin Cancer | 21984974 | ENSP00000316845 | S160R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000348017 | *620Y | COSMIC | Intestines Cancer | 16959974 | ENSP00000432267 | D417N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000316845 | K100R | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000348017 | D346N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000316845 | D417N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000316845 | T441R | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000376680 | D417N | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ARHG4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ARHG4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SCMC3_HUMAN | ARHG4_HUMAN | other | KEGG |
| ARHG4_HUMAN | RAC1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IMP | molecular_function |
| GO:0046847 | filopodium assembly | IMP | biological_process |
| GO:0035556 | intracellular signal transduction | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035023 | regulation of Rho protein signal transduction | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0030032 | lamellipodium assembly | IMP | biological_process |
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | IMP | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | NAS | molecular_function |
| GO:0032587 | ruffle membrane | IEA | cellular_component |