Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARHG4_HUMAN
Description:Rho guanine nucleotide exchange factor (GEF) 4 [Source:HGNC Symbol;Acc:684]
Location:chr2 q21.1
Node attribute:PPI(target); PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S280AEAQSsKDQMRPhosphoSitePlus
S279GAEAQsSKDQMPhosphoSitePlus
T286KDQMRtNVINEPhosphoSitePlus

Dephosphorylation site
ARHG4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000316845C314YCOSMICMelanoma
ENSP00000316845S160RTCGAOvarian Cancer21720365, 18772890
ENSP00000316845D534NCOSMICSkin Cancer21984974
ENSP00000316845S160RCOSMICOvarian Cancer21720365
ENSP00000348017*620YCOSMICIntestines Cancer16959974
ENSP00000432267D417NBIOMARTBreast Cancer21930507, 21930502
ENSP00000316845K100RSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000348017D346NBIOMARTBreast Cancer21930507, 21930502
ENSP00000316845D417NBIOMARTBreast Cancer21930507, 21930502
ENSP00000316845T441RSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000376680D417NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ARHG4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARHG4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SCMC3_HUMANARHG4_HUMANotherKEGG
ARHG4_HUMANRAC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005085guanyl-nucleotide exchange factor activityIMPmolecular_function
GO:0046847filopodium assemblyIMPbiological_process
GO:0035556intracellular signal transductionNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0019904protein domain specific bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0030032lamellipodium assemblyIMPbiological_process
GO:0030676Rac guanyl-nucleotide exchange factor activityIMPmolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityNASmolecular_function
GO:0032587ruffle membraneIEAcellular_component


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