Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL3RB_HUMAN
Description:colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [Source:HGNC Symbol;Acc:2436]
Location:chr22 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S601PPHSRsLPDILPKA_groupphosphoELM
Y766SGFEGyVELPPPhosphoSitePlus; HPRD; phosphoELM
Y711GVASGyVSSADPhosphoSitePlus; HPRD; phosphoELM
Y822QQVGDyCFLPGPhosphoSitePlus; phosphoELM
Y466RFCGIyGYRLRPhosphoSitePlus
S585PEKQAsSFDFNHPRD
Y628PGSLEyLCLPAPhosphoSitePlus; HPRD; phosphoELM
Y593DFNGPyLGPPHPhosphoSitePlus; HPRD; phosphoELM
S601PPHSRsLPDILPhosphoSitePlus; phosphoELM
Y882LKQQDyLSLPPPhosphoSitePlus
S491LFQNGsAELWPPhosphoSitePlus
Y468CGIYGyRLRRKPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y628PPPGSLEyLCLPAGGPTPN11HPRD
Y628PPPGSLEyLCLPAGGPTPN6HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384053A394VBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
IL3RB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S601LGPPHSRsLPDILGQacute myelogenous leukemia19805619PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PTN6_HUMANIL3RB_HUMANphosphatase -> substrateHPRD
PTN11_HUMANIL3RB_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04210Apoptosis
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0007165signal transductionNASbiological_process
GO:0004896cytokine receptor activityIEAmolecular_function
GO:0007585respiratory gaseous exchangeTASbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004912interleukin-3 receptor activityTASmolecular_function
GO:0038043interleukin-5-mediated signaling pathwayTASbiological_process
GO:0030526granulocyte macrophage colony-stimulating factor rTAScellular_component
GO:0004872receptor activityTASmolecular_function
GO:0036016cellular response to interleukin-3TASbiological_process
GO:0004914interleukin-5 receptor activityTASmolecular_function
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0038156interleukin-3-mediated signaling pathwayTASbiological_process


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