| UniProt/SwissProt ID: | MAGI3_HUMAN |
| Description: | membrane associated guanylate kinase, WW and PDZ domain containing 3 [Source:HGNC Symbol;Acc:29647] |
| Location: | chr1 p13.2 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S225 | RKRTTsVSKME | PhosphoSitePlus | |
| Y116 | KDLRHyLSLQF | PhosphoSitePlus | |
| T147 | TIPCTtRAPRD | Guanylate_kin | PhosphoSitePlus |
| S235 | ERMDSsLPEEE | PhosphoSitePlus | |
| S1282 | RDQSLsPSKGE | PhosphoSitePlus | |
| T224 | QRKRTtSVSKM | PhosphoSitePlus | |
| S1284 | QSLSPsKGENK | PhosphoSitePlus | |
| S118 | LRHYLsLQFQK | PhosphoSitePlus | |
| S1280 | RPRDQsLSPSK | PhosphoSitePlus | |
| S234 | MERMDsSLPEE | PhosphoSitePlus | |
| T102 | PIRLKtVKPGK | PhosphoSitePlus | |
| S1059 | RGFGFsLRGGK | PDZ | PhosphoSitePlus |
| S595 | FAIADsPTGQK | HPRD | |
| Y875 | APQEPyDVVLQ | PhosphoSitePlus | |
| Dephosphorylation site |
| MAGI3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358628 | T929I | COSMIC | Skin Cancer | 21984974 | ENSP00000358628 | R766P | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000358628 | L897V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358628 | R768L | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000358628 | G946E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358624 | D892H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358628 | Q529* | COSMIC | Lung Cancer | 20668451 | ENSP00000358628 | K7R | COSMIC | Lung Cancer | 20668451 | ENSP00000358628 | D892H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358628 | G737A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358628 | R808W | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| MAGI3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MAGI3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MAGI3_HUMAN | PTEN_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | NAS | biological_process |
| GO:0005911 | cell-cell junction | IEA | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016020 | membrane | NAS | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005923 | tight junction | IEA | cellular_component |
| GO:0035556 | intracellular signal transduction | NAS | biological_process |
| GO:0004385 | guanylate kinase activity | NAS | molecular_function |
| GO:0043507 | positive regulation of JUN kinase activity | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005109 | frizzled binding | IEA | molecular_function |