Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RO52_HUMAN
Description:tripartite motif containing 21 [Source:HGNC Symbol;Acc:11312]
Location:chr11 p15.4
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S266DLDITsPELRSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S469PLNIGsQGSTDPhosphoSitePlus
S447LRPFFsPGFNDSPRYPhosphoSitePlus
Y393YEAGTyPQTPLSPRYPhosphoSitePlus

Dephosphorylation site
RO52_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254436E192QCOSMICOvarian Cancer21720365
ENSP00000254436V250LCOSMICOvarian Cancer21720365
ENSP00000254436A437TCOSMICOvarian Cancer21720365

Differential expressed protein
RO52_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RO52_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MP2K7_HUMANRO52_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RO52_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070206protein trimerizationIDAbiological_process
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0019005SCF ubiquitin ligase complexIDAcellular_component
GO:0000932cytoplasmic mRNA processing bodyIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0000151ubiquitin ligase complexIEAcellular_component
GO:0030529ribonucleoprotein complexTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0006513protein monoubiquitinationIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0016567protein ubiquitinationIDAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0007049cell cycleIEAbiological_process
GO:0090086negative regulation of protein deubiquitinationIMPbiological_process
GO:0031648protein destabilizationIMPbiological_process
GO:0045787positive regulation of cell cycleIMPbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process


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