Phosphorylation

Protein information

UniProt/SwissProt ID:	M3K12_HUMAN
Description:	mitogen-activated protein kinase kinase kinase 12 [Source:HGNC Symbol;Acc:6851]
Location:	chr12 q13.13
Node attribute:	kinase

Position	PhosphoPeptide	Source
S634	AGDPGsPPPAR	PhosphoSitePlus
S757	SSENPsDGEEG	PhosphoSitePlus

M3K12_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000267079	E409K	HPI	Breast Cancer	17344846
ENSP00000267079	L237F	Ding2008, BIOMART	Lung Cancer	18948947, 21930507, 21930502
ENSP00000267079	G690R	Ding2008, BIOMART	Lung Cancer	18948947, 21930507, 21930502

M3K12_HUMAN is not differential expressed protein.

M3K12_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
M3K12_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG

KEGG Pathway

KEGG ID	Pathway
hsa04010	MAPK signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0000186	activation of MAPKK activity	IEA	biological_process
GO:0030426	growth cone	IEA	cellular_component
GO:0007254	JNK cascade	ISS	biological_process
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005886	plasma membrane	IEA	cellular_component
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0046777	protein autophosphorylation	IEA	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0000287	magnesium ion binding	IEA	molecular_function
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0042803	protein homodimerization activity	IEA	molecular_function
GO:0018107	peptidyl-threonine phosphorylation	IEA	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0006468	protein phosphorylation	ISS	biological_process
GO:0016572	histone phosphorylation	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0033267	axon part	IEA	cellular_component
GO:0007243	intracellular protein kinase cascade	TAS	biological_process
GO:0019901	protein kinase binding	IPI	molecular_function
GO:0005737	cytoplasm	TAS	cellular_component
GO:0016020	membrane	ISS	cellular_component
GO:0018105	peptidyl-serine phosphorylation	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network