Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDE5A_HUMAN
Description:phosphodiesterase 5A, cGMP-specific [Source:HGNC Symbol;Acc:8784]
Location:chr4 q26
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S92PRADNsAPGTPPhosphoSitePlus
S60PTRKIsASEFDPRKG1HPRD
S102PTRKIsASEFDPKG1/cGK-IphosphoELM
S102PTRKIsASEFDPKA_groupphosphoELM; RegPhos
S102PTRKIsASEFDPKG/cGK_groupphosphoELM
S869LINGEsGQAKRPhosphoSitePlus
S86CPLQQsPRADNPhosphoSitePlus
S102PTRKIsASEFDPhosphoSitePlus; phosphoELM; RegPhos
T137EQMPLtPPRFDPhosphoSitePlus
S102PTRKIsASEFDPRKG1HPRD
S102PTRKIsASEFDPKG_groupRegPhos
S102PTRKIsASEFDPKG1RegPhos

Dephosphorylation site
PDE5A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264805K88NBIOMARTBreast Cancer21930507, 21930502
ENSP00000347046K130NBIOMARTBreast Cancer21930507, 21930502
ENSP00000347046R874QCOSMICSkin Cancer21984974

Differential expressed protein
PDE5A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDE5A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPDE5A_HUMANkinase -> substrateRegPhos
KGP1_HUMANPDE5A_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00230Purine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0008270zinc ion bindingNASmolecular_function
GO:0010613positive regulation of cardiac muscle hypertrophyIEAbiological_process
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0046068cGMP metabolic processIEAbiological_process
GO:0005575cellular_componentNDcellular_component
GO:0055118negative regulation of cardiac muscle contractionIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0030553cGMP bindingIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0004112cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:0055119relaxation of cardiac muscleIEAbiological_process
GO:0009187cyclic nucleotide metabolic processNASbiological_process
GO:00475553',5'-cyclic-GMP phosphodiesterase activityIEAmolecular_function
GO:0046069cGMP catabolic processIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0060282positive regulation of oocyte developmentIEAbiological_process


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