Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BACE1_HUMAN
Description:beta-site APP-cleaving enzyme 1 [Source:HGNC Symbol;Acc:933]
Location:chr11 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y260RREWYyEVIIVAspPhosphoSitePlus
S429FADDIsLCSNK1DHPRD
S498FADDIsLLK__PhosphoSitePlus
S473FADDIsLCSNK1DHPRD
S498FADDIsLLKCK1dRegPhos
S498FADDIsLCK1_alphaphosphoELM
S498FADDIsLCK1_deltaphosphoELM
S498FADDIsLLKCK1d(CK1 deltaRegPhos
S498FADDIsLLKCK1a(CK1 alphaRegPhos
S498FADDIsLCSNK1DHPRD
S71NLRGKsGQGYYPhosphoSitePlus
S454FADDIsLCSNK1DHPRD
S308EAAVKsIKAASAspPhosphoSitePlus

Dephosphorylation site
BACE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318585F60LCOSMICOvarian Cancer21720365
ENSP00000318585A419GCOSMICOvarian Cancer21720365
ENSP00000424536R189MBIOMARTBreast Cancer21930507, 21930502
ENSP00000318585R189MBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
BACE1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BACE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1A_HUMANBACE1_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANBACE1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004190aspartic-type endopeptidase activityIDAmolecular_function
GO:0030424axonIEAcellular_component
GO:0008798beta-aspartyl-peptidase activityTASmolecular_function
GO:0005802trans-Golgi networkIDAcellular_component
GO:0030659cytoplasmic vesicle membraneIEAcellular_component
GO:0006509membrane protein ectodomain proteolysisTASbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0050435beta-amyloid metabolic processIDAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:0006508proteolysisIDAbiological_process
GO:0005768endosomeIDAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0016021integral to membraneNAScellular_component


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