| UniProt/SwissProt ID: | IFNA1_HUMAN |
| Description: | interferon, alpha 1 [Source:HGNC Symbol;Acc:5417] |
| Location: | chr9 p21.3 |
| Node attribute: | gene |
| Phosphorylation site |
| IFNA1_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| IFNA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000276927 | D25G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000276927 | D25G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000276927 | R148G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000276927 | R148G | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| IFNA1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IFNA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IRF7_HUMAN | IFNA1_HUMAN | TF -> target gene | KEGG |
| IRF7_HUMAN | IFNA1_HUMAN | TF -> target gene | TRANSFAC |
| IRF1_HUMAN | IFNA1_HUMAN | TF -> target gene | TRANSFAC |
| IRF3_HUMAN | IFNA1_HUMAN | TF -> target gene | TRANSFAC |
| IRF5_HUMAN | IFNA1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04622 | RIG-I-like receptor signaling pathway |
| hsa05162 | Measles |
| hsa05320 | Autoimmune thyroid disease |
| hsa05152 | Tuberculosis |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04140 | Regulation of autophagy |
| hsa05168 | Herpes simplex infection |
| hsa04623 | Cytosolic DNA-sensing pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05164 | Influenza A |
| hsa04630 | Jak-STAT signaling pathway |
| hsa05160 | Hepatitis C |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0005126 | cytokine receptor binding | IEA | molecular_function |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0060338 | regulation of type I interferon-mediated signaling | TAS | biological_process |
| GO:0006952 | defense response | IEA | biological_process |
| GO:0005132 | interferon-alpha/beta receptor binding | TAS | molecular_function |