Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD80_HUMAN
Description:CD80 molecule [Source:HGNC Symbol;Acc:1700]
Location:chr3 q13.33
Node attribute:PPI(target); PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S284RLRREsVRPV_PhosphoSitePlus

Dephosphorylation site
CD80_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264246V225ECOSMICOvarian Cancer21720365
ENSP00000264246E86KCOSMICHead and Neck Cancer21984974
ENSP00000264246S165FBIOMARTBreast Cancer21930507, 21930502
ENSP00000418364S165FBIOMARTBreast Cancer21930507, 21930502
ENSP00000264246F19LCOSMICHead and Neck Cancer21798897

Differential expressed protein
CD80_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD80_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CD80_HUMANCD28_HUMANotherKEGG
CD28_HUMANCD80_HUMANotherKEGG
CD80_HUMANCTLA4_HUMANotherKEGG
IRF3_HUMANCD80_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa04620Toll-like receptor signaling pathway
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa04514Cell adhesion molecules (CAMs)
hsa05323Rheumatoid arthritis
hsa05416Viral myocarditis
hsa05322Systemic lupus erythematosus

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneICcellular_component
GO:0009897external side of plasma membraneIEAcellular_component
GO:0035556intracellular signal transductionNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045627positive regulation of T-helper 1 cell differentiaNASbiological_process
GO:0015026coreceptor activityNASmolecular_function
GO:0031295T cell costimulationIEAbiological_process
GO:0042110T cell activationICbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0045086positive regulation of interleukin-2 biosynthetic NASbiological_process
GO:0045425positive regulation of granulocyte macrophage coloNASbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0009967positive regulation of signal transductionNASbiological_process
GO:0007267cell-cell signalingICbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0005515protein bindingIPImolecular_function


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