| UniProt/SwissProt ID: | ISG15_HUMAN |
| Description: | ISG15 ubiquitin-like modifier [Source:HGNC Symbol;Acc:4053] |
| Location: | chr1 p36.33 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S26 | SSMSVsELKAQ | HPRD | |
| Dephosphorylation site |
| ISG15_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ISG15_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000368699 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.35 | 18646787 | ENSP00000368699 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.045 | 18646787 | ENSP00000368699 | Oral Cancer | Normal vs. Cancer | tissue | Up | 21 | 19297561 | ENSP00000368699 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.44 | 20739354 |
| Hyperphosphorylation site |
| ISG15_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IRF7_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| IRF3_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| IRF1_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| IRF4_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| SPI1_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| IRF8_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| IRF9_HUMAN | ISG15_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ISG15_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005615 | extracellular space | NAS | cellular_component |
| GO:0019941 | modification-dependent protein catabolic process | IEA | biological_process |
| GO:0032020 | ISG15-protein conjugation | IEA | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0032480 | negative regulation of type I interferon productio | TAS | biological_process |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0031386 | protein tag | IEA | molecular_function |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | NAS | cellular_component |
| GO:0007267 | cell-cell signaling | NAS | biological_process |
| GO:0032020 | ISG15-protein conjugation | IDA | biological_process |