| UniProt/SwissProt ID: | CD86_HUMAN |
| Description: | CD86 molecule [Source:HGNC Symbol;Acc:1705] |
| Location: | chr3 q13.33 |
| Node attribute: | PPI(source); gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y108 | KDKGLyQCIIH | V-set | PhosphoSitePlus |
| Dephosphorylation site |
| CD86_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000332049 | W268* | COSMIC | Melanoma | 21499247 | ENSP00000332049 | K188E | COSMIC | Pancreatic Cancer | ENSP00000332049 | N135H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000332049 | L63V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CD86_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD86_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CD86_HUMAN | CD28_HUMAN | other | KEGG |
| CD86_HUMAN | CTLA4_HUMAN | other | KEGG |
| IRF3_HUMAN | CD86_HUMAN | TF -> target gene | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05202 | Transcriptional misregulation in cancer |
| hsa05320 | Autoimmune thyroid disease |
| hsa04672 | Intestinal immune network for IgA production |
| hsa05322 | Systemic lupus erythematosus |
| hsa04940 | Type I diabetes mellitus |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa05330 | Allograft rejection |
| hsa05416 | Viral myocarditis |
| hsa05323 | Rheumatoid arthritis |
| hsa05332 | Graft-versus-host disease |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0045630 | positive regulation of T-helper 2 cell differentia | NAS | biological_process |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0043017 | positive regulation of lymphotoxin A biosynthetic | NAS | biological_process |
| GO:0042110 | T cell activation | IC | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0045404 | positive regulation of interleukin-4 biosynthetic | NAS | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0042113 | B cell activation | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0015026 | coreceptor activity | NAS | molecular_function |
| GO:0007267 | cell-cell signaling | IC | biological_process |
| GO:0016021 | integral to membrane | IC | cellular_component |
| GO:0045086 | positive regulation of interleukin-2 biosynthetic | NAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0002224 | toll-like receptor signaling pathway | IEA | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |