| UniProt/SwissProt ID: | ANT3_HUMAN |
| Description: | serpin peptidase inhibitor, clade C (antithrombin), member 1 [Source:HGNC Symbol;Acc:775] |
| Location: | chr1 q25.1 |
| Node attribute: | ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S174 | SSKLVsANRLF | Serpin | PhosphoSitePlus |
| S68 | TEDEGsEQKIP | PhosphoSitePlus; HPRD | |
| S174 | SSKLVsANRLF | HPRD | |
| T63 | PEKKAtEDEGS | PhosphoSitePlus; HPRD | |
| T10 | VIGTVtSGKRK | PhosphoSitePlus | |
| Y272 | RKELFyKADGE | Serpin | PhosphoSitePlus |
| S214 | ENAEQsRAAIN | Serpin | PhosphoSitePlus |
| S57 | MCIYRsPEKKA | PhosphoSitePlus | |
| Dephosphorylation site |
| ANT3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356671 | S426L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356671 | K254E | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356671 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 3.1 | 16212428 | ENSP00000356671 | breast ductal carcinoma | Metastasis | tissue | Up | 19624269 | ENSP00000356671 | Brain Cancer | Normal vs. Cancer | tissue | Up | 2.8 | 18056677 | ENSP00000356671 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 19471570 |
| Hyperphosphorylation site |
| ANT3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ANT3_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| CEBPA_HUMAN | ANT3_HUMAN | TF -> target gene | TRANSFAC |
| HNF4A_HUMAN | ANT3_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010951 | negative regulation of endopeptidase activity | IBA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007584 | response to nutrient | IEA | biological_process |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004867 | serine-type endopeptidase inhibitor activity | IBA | molecular_function |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0002020 | protease binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0050728 | negative regulation of inflammatory response | IEA | biological_process |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0030162 | regulation of proteolysis | IBA | biological_process |