Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ANT3_HUMAN
Description:serpin peptidase inhibitor, clade C (antithrombin), member 1 [Source:HGNC Symbol;Acc:775]
Location:chr1 q25.1
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S174SSKLVsANRLFSerpinPhosphoSitePlus
S68TEDEGsEQKIPPhosphoSitePlus; HPRD
S174SSKLVsANRLFHPRD
T63PEKKAtEDEGSPhosphoSitePlus; HPRD
T10VIGTVtSGKRKPhosphoSitePlus
Y272RKELFyKADGESerpinPhosphoSitePlus
S214ENAEQsRAAINSerpinPhosphoSitePlus
S57MCIYRsPEKKAPhosphoSitePlus

Dephosphorylation site
ANT3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356671S426LCOSMICOvarian Cancer21720365
ENSP00000356671K254ECOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356671Pancreatic CancerNormal vs. CancertissueDown3.116212428
ENSP00000356671breast ductal carcinomaMetastasistissueUp19624269
ENSP00000356671Brain CancerNormal vs. CancertissueUp2.818056677
ENSP00000356671Uterine CancerNormal vs. CancertissueDown19471570

Hyperphosphorylation site
ANT3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANT3_HUMANLRP1_HUMANligand -> receptorHPMR
CEBPA_HUMANANT3_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANANT3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010951negative regulation of endopeptidase activityIBAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0007584response to nutrientIEAbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004867serine-type endopeptidase inhibitor activityIBAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0005576extracellular regionNAScellular_component
GO:0002020protease bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0030162regulation of proteolysisIBAbiological_process


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