| UniProt/SwissProt ID: | CP27A_HUMAN |
| Description: | cytochrome P450, family 27, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:2605] |
| Location: | chr2 q35 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y397 | ETLRLyPVVPT | p450 | PhosphoSitePlus |
| S321 | ASGQLsPREAM | p450 | PhosphoSitePlus |
| S280 | WNAIFsFGKKL | p450 | PhosphoSitePlus |
| S321 | ASGQLsPREAM | HPRD | |
| Dephosphorylation site |
| CP27A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258415 | P302S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000258415 | *532R | COSMIC | Breast Cancer | 20668451 | ENSP00000258415 | P302S | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CP27A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CP27A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HNF4A_HUMAN | CP27A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CP27A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006699 | bile acid biosynthetic process | TAS | biological_process |
| GO:0031073 | cholesterol 26-hydroxylase activity | IEA | molecular_function |
| GO:0047749 | cholestanetriol 26-monooxygenase activity | IEA | molecular_function |
| GO:0016705 | oxidoreductase activity, acting on paired donors, | IEA | molecular_function |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005506 | iron ion binding | IEA | molecular_function |
| GO:0055114 | oxidation-reduction process | IEA | biological_process |
| GO:0020037 | heme binding | IEA | molecular_function |
| GO:0005743 | mitochondrial inner membrane | IEA | cellular_component |
| GO:0030343 | vitamin D3 25-hydroxylase activity | IEA | molecular_function |
| GO:0006805 | xenobiotic metabolic process | TAS | biological_process |
| GO:0008395 | steroid hydroxylase activity | TAS | molecular_function |
| GO:0008206 | bile acid metabolic process | TAS | biological_process |
| GO:0005740 | mitochondrial envelope | IEA | cellular_component |
| GO:0009055 | electron carrier activity | IEA | molecular_function |
| GO:0008203 | cholesterol metabolic process | IEA | biological_process |