Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPO_HUMAN
Description:erythropoietin [Source:HGNC Symbol;Acc:3415]
Location:chr7 q22.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S131VSGLRsLTTLLEPO_TPOPhosphoSitePlus
S127VDKAVsGLRSLHPRD
S111ALLVNsSQPWEHPRD
S127VDKAVsGLRSLEPO_TPOPhosphoSitePlus

Dephosphorylation site
EPO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000252723P149QHPIHepatocellular Carcinoma8396923
ENSP00000252723R103WCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
EPO_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HNF4A_HUMANEPO_HUMANTF -> target geneTRANSFAC
COT1_HUMANEPO_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
EPO_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionNASbiological_process
GO:0032413negative regulation of ion transmembrane transportIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0009651response to salt stressIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0048678response to axon injuryIEAbiological_process
GO:0042541hemoglobin biosynthetic processIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005128erythropoietin receptor bindingIEAmolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0033033negative regulation of myeloid cell apoptotic procIEAbiological_process
GO:0033574response to testosterone stimulusIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0046579positive regulation of Ras protein signal transducIDAbiological_process
GO:0008015blood circulationNASbiological_process
GO:0007566embryo implantationIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0005179hormone activityIEAmolecular_function
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0070555response to interleukin-1IEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0007584response to nutrientIEAbiological_process
GO:0033554cellular response to stressTASbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0061418regulation of transcription from RNA polymerase IITASbiological_process
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0043249erythrocyte maturationIEAbiological_process
GO:0055093response to hyperoxiaIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0033189response to vitamin AIEAbiological_process
GO:0051602response to electrical stimulusIEAbiological_process
GO:0071474cellular hyperosmotic responseIDAbiological_process
GO:0010766negative regulation of sodium ion transportIDAbiological_process
GO:0030295protein kinase activator activityIEAmolecular_function