Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CP3A4_HUMAN
Description:cytochrome P450, family 3, subfamily A, polypeptide 4 [Source:HGNC Symbol;Acc:2637]
Location:chr7 q22.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S420LPERFsKKNKDp450PhosphoSitePlus
T264SRLEDtQKHRVp450PhosphoSitePlus
S100VKECYsVFTNRp450PhosphoSitePlus
S139SPTFTsGKLKEp450PhosphoSitePlus
T409DPKYWtEPEKFp450PhosphoSitePlus
S119MKSAIsIAEDEp450PhosphoSitePlus
S134LRSLLsPTFTSp450PhosphoSitePlus
T136SLLSPtFTSGKp450PhosphoSitePlus
S398VVMIPsYALHRp450PhosphoSitePlus
S131WKRLRsLLSPTp450PhosphoSitePlus
T103CYSVFtNRRPFp450PhosphoSitePlus
S478IPLKLsLGGLLp450PhosphoSitePlus
Y347KAPPTyDTVLQp450PhosphoSitePlus
T284QNSKEtESHKAp450PhosphoSitePlus
S259KRMKEsRLEDTp450PhosphoSitePlus
T92PDMIKtVLVKEp450PhosphoSitePlus
Y432IDPYIyTPFGSp450PhosphoSitePlus

Dephosphorylation site
CP3A4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337915D6NCOSMICCentral Nervous System Neoplasms18772890
ENSP00000337915F213IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000337915V20MCOSMICCentral Nervous System Neoplasms18772890
ENSP00000337915M9VCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000337915hepatitis C virusNormal vs. CancertissueDown0.218715028

Hyperphosphorylation site
CP3A4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
USF1_HUMANCP3A4_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANCP3A4_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANCP3A4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CP3A4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0047638albendazole monooxygenase activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0030343vitamin D3 25-hydroxylase activityIDAmolecular_function
GO:0008209androgen metabolic processTASbiological_process
GO:0042737drug catabolic processIDAbiological_process
GO:0033780taurochenodeoxycholate 6alpha-hydroxylase activityIEAmolecular_function
GO:0020037heme bindingIEAmolecular_function
GO:0042738exogenous drug catabolic processIDAbiological_process
GO:0004497monooxygenase activityISSmolecular_function
GO:0046483heterocycle metabolic processIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006629lipid metabolic processTASbiological_process
GO:0070989oxidative demethylationIDAbiological_process
GO:0043231intracellular membrane-bounded organelleTAScellular_component
GO:0016705oxidoreductase activity, acting on paired donors, IEAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0034875caffeine oxidase activityIDAmolecular_function
GO:0070576vitamin D 24-hydroxylase activityIDAmolecular_function
GO:0016098monoterpenoid metabolic processIDAbiological_process
GO:0005496steroid bindingIDAmolecular_function
GO:0009055electron carrier activityIEAmolecular_function
GO:0017144drug metabolic processIDAbiological_process
GO:0050649testosterone 6-beta-hydroxylase activityIMPmolecular_function
GO:0019825oxygen bindingTASmolecular_function
GO:0008202steroid metabolic processIMPbiological_process
GO:0016491oxidoreductase activityIDAmolecular_function
GO:0042359vitamin D metabolic processICbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0008395steroid hydroxylase activityIMPmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0009822alkaloid catabolic processIDAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0050591quinine 3-monooxygenase activityIEAmolecular_function
GO:0055114oxidation-reduction processIDAbiological_process
GO:0006706steroid catabolic processIMPbiological_process
GO:0006805xenobiotic metabolic processTASbiological_process
GO:0005506iron ion bindingIDAmolecular_function
GO:0016712oxidoreductase activity, acting on paired donors, IEAmolecular_function


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