Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AK1C4_HUMAN
Description:aldo-keto reductase family 1, member C4 [Source:HGNC Symbol;Acc:387]
Location:chrHG871_PATCH p15.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y305NRNYRyVVMDFPhosphoSitePlus
Y24LGFGTyAPPEVAldo_ket_redPhosphoSitePlus
Y272VLAKSyNEQRIAldo_ket_redPhosphoSitePlus
S200PYLNQsKLLDFAldo_ket_redPhosphoSitePlus
T23VLGFGtYAPPEAldo_ket_redPhosphoSitePlus
S208LDFCKsKDIVLAldo_ket_redPhosphoSitePlus
Y196VECHPyLNQSKHPRD
Y53HIDSAyLYNNEAldo_ket_redPhosphoSitePlus
Y184KPGLKyKPVCNAldo_ket_redPhosphoSitePlus
Y81REDIFyTSKLWAldo_ket_redPhosphoSitePlus
Y317MDHPDyPFSDEPhosphoSitePlus
Y196VECHPyLNQSKAldo_ket_redPhosphoSitePlus
T82EDIFYtSKLWCAldo_ket_redPhosphoSitePlus

Dephosphorylation site
AK1C4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000369814E149ATCGAOvarian Cancer21720365, 18772890
ENSP00000369814E149ACOSMICOvarian Cancer21720365
ENSP00000263126E149ATCGAOvarian Cancer21720365, 18772890
ENSP00000369814L311VBIOMARTGastric Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263126Hepatocellular CarcinomaNormal vs. CancertissueDown18571811
ENSP00000263126Uterine CancerNormal vs. CancertissueDown16051329
ENSP00000263126Uterine CancerNormal vs. CancertissueDown19771267

Hyperphosphorylation site
AK1C4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HNF4G_HUMANAK1C4_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANAK1C4_HUMANTF -> target geneTRANSFAC
HNF4A_HUMANAK1C4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
AK1C4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0047023androsterone dehydrogenase activityIDAmolecular_function
GO:0047743chlordecone reductase activityIEAmolecular_function
GO:0001758retinal dehydrogenase activityIDAmolecular_function
GO:0015721bile acid and bile salt transportTASbiological_process
GO:0016655oxidoreductase activity, acting on NAD(P)H, quinonIDAmolecular_function
GO:0015125bile acid transmembrane transporter activityTASmolecular_function
GO:0071395cellular response to jasmonic acid stimulusIDAbiological_process
GO:0006699bile acid biosynthetic processTASbiological_process
GO:0008209androgen metabolic processTASbiological_process
GO:0008202steroid metabolic processTASbiological_process
GO:0009055electron carrier activityTASmolecular_function
GO:0044597daunorubicin metabolic processIMPbiological_process
GO:0044598doxorubicin metabolic processIMPbiological_process
GO:0047042androsterone dehydrogenase (B-specific) activityIEAmolecular_function
GO:0004033aldo-keto reductase (NADP) activityTASmolecular_function
GO:0008206bile acid metabolic processTASbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process


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