| UniProt/SwissProt ID: | RPGF1_HUMAN |
| Description: | Rap guanine nucleotide exchange factor (GEF) 1 [Source:HGNC Symbol;Acc:4568] |
| Location: | chr9 q34.13 |
| Node attribute: | PPI(source); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y61 | FLPEGyPLPLD | PhosphoSitePlus | |
| T950 | EWQKQtSEGLA | RasGEF | PhosphoSitePlus |
| T572 | SMFYQtPQNEH | PhosphoSitePlus | |
| Y561 | QLLEDySEPQP | PhosphoSitePlus | |
| T328 | PMSRAtSGSSL | HPRD | |
| S966 | IDSSSsFRAYR | RasGEF | PhosphoSitePlus |
| S293 | PKKRQsAPSPT | PhosphoSitePlus | |
| T127 | LRYFKtIVDKM | HPRD | |
| S314 | ATSGSsLPVGI | PhosphoSitePlus; HPRD; RegPhos | |
| S378 | GKLSKsDEQLS | HPRD | |
| S345 | SYGGEsPRLSP | PhosphoSitePlus | |
| S965 | LIDSSsSFRAY | RasGEF | PhosphoSitePlus |
| Y390 | HYDPDyEFLQQ | PhosphoSitePlus | |
| Y504 | IPSVPyAPFAA | HCK | HPRD; phosphoELM; RegPhos |
| Y504 | IPSVPyAPFAA | Src | RegPhos |
| S307 | VVAPMsRATSG | PhosphoSitePlus | |
| Y504 | IPSVPyAPFAA | SRC | phosphoELM |
| S352 | RLSPCsSIGKL | PhosphoSitePlus | |
| S652 | ERAPKsPDALE | PhosphoSitePlus | |
| S296 | RQSAPsPTRVA | PhosphoSitePlus | |
| S951 | WQKQTsEGLAE | RasGEF | PhosphoSitePlus |
| T298 | SAPSPtRVAVV | HPRD | |
| Y522 | IPSVPyAPFAA | HCK | HPRD |
| T261 | LLPDAtDEEVA | PhosphoSitePlus | |
| S463 | EKKRRsAASQT | PhosphoSitePlus | |
| T1067 | KPRNItRRKTD | PhosphoSitePlus | |
| Y715 | KDLVLyCEAFL | RasGEF_N | PhosphoSitePlus |
| S332 | ATSGSsLPVGI | HPRD | |
| T316 | SAPSPtRVAVV | HPRD | |
| S349 | ESPRLsPCSSI | PhosphoSitePlus | |
| Y329 | FDVDCyAQRRL | PhosphoSitePlus | |
| S360 | GKLSKsDEQLS | PhosphoSitePlus; HPRD; RegPhos | |
| S311 | MSRATsGSSLP | PhosphoSitePlus; HPRD; RegPhos | |
| Y570 | QPSMFyQTPQN | PhosphoSitePlus | |
| T109 | LRYFKtIVDKM | PhosphoSitePlus; HPRD | |
| T819 | LLRCAtSSQPL | PhosphoSitePlus | |
| T310 | PMSRAtSGSSL | PhosphoSitePlus; HPRD; RegPhos | |
| S820 | LRCATsSQPLA | PhosphoSitePlus | |
| S281 | RVVDNsPPPAL | PhosphoSitePlus | |
| S466 | RRSAAsQTADG | PhosphoSitePlus | |
| S423 | LGESGsPFLGP | PhosphoSitePlus | |
| Y579 | QNEHIyQQKNK | PhosphoSitePlus | |
| S329 | MSRATsGSSLP | HPRD | |
| Y723 | AFLTTyRTFIS | RasGEF_N | PhosphoSitePlus |
| S371 | SLDRDsGQCSR | PhosphoSitePlus | |
| S335 | AQRRLsGGSHS | PhosphoSitePlus | |
| T1071 | ITRRKtDREEK | PhosphoSitePlus | |
| Y504 | IPSVPyAPFAA | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| RPGF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361264 | S908F | COSMIC | Melanoma | ENSP00000361264 | F39L | COSMIC | Lung Cancer | 18948947 | ENSP00000361264 | G846W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361264 | K940E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361264 | P76T | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| RPGF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RPGF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HCK_HUMAN | RPGF1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | RPGF1_HUMAN | kinase -> substrate | RegPhos |
| RPGF1_HUMAN | RHOQ_HUMAN | other | KEGG |
| RPGF1_HUMAN | RAP1A_HUMAN | other | KEGG |
| CRK_HUMAN | RPGF1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04722 | Neurotrophin signaling pathway |
| hsa04510 | Focal adhesion |
| hsa05211 | Renal cell carcinoma |
| hsa04910 | Insulin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016337 | cell-cell adhesion | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0001568 | blood vessel development | IEA | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |
| GO:0048008 | platelet-derived growth factor receptor signaling | IEA | biological_process |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | TAS | biological_process |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005768 | endosome | TAS | cellular_component |
| GO:0000186 | activation of MAPKK activity | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |