| UniProt/SwissProt ID: | CLK1_HUMAN |
| Description: | CDC-like kinase 1 [Source:HGNC Symbol;Acc:2068] |
| Location: | chr2 q33.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y80 | EYRNDyTQGCE | PhosphoSitePlus | |
| S61 | YLESRsINEKD | PhosphoSitePlus; HPRD | |
| S337 | DDEHHsTLVST | Pkinase | PhosphoSitePlus |
| Y331 | FGSATyDDEHH | HPRD | |
| T330 | DFGSAtYDDEH | HPRD | |
| Y345 | VSTRHyRAPEV | Pkinase | PhosphoSitePlus |
| T338 | DEHHStLVSTR | HPRD; phosphoELM | |
| S59 | SHYLEsRSINE | PhosphoSitePlus | |
| T342 | STLVStRHYRA | HPRD | |
| T338 | DEHHStLVSTR | Pkinase | PhosphoSitePlus |
| Y76 | RYIDEyRNDYT | PhosphoSitePlus | |
| S341 | HSTLVsTRHYR | HPRD | |
| T342 | STLVStRHYRA | Pkinase | PhosphoSitePlus |
| Y345 | VSTRHyRAPEV | HPRD | |
| Y56 | MCDSHyLESRS | PhosphoSitePlus | |
| S337 | DDEHHsTLVST | HPRD; phosphoELM | |
| S140 | RKRTRsVEDDE | PhosphoSitePlus; HPRD; phosphoELM | |
| S37 | KRSHSsAQENK | PhosphoSitePlus; HPRD | |
| T138 | HRRKRtRSVED | PhosphoSitePlus; HPRD; phosphoELM | |
| S24 | YGKWRsSSSHK | PhosphoSitePlus | |
| T123 | RIHHStSHRRS | PhosphoSitePlus | |
| S328 | VVDFGsATYDD | HPRD | |
| S341 | HSTLVsTRHYR | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| CLK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CLK1_HUMAN do not have mutation site. |
| Differential expressed protein |
| CLK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CLK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK1_HUMAN | RFA2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZN471_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK13_HUMAN | CLK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | GMEB1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | PRS6A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | VHL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZN396_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | CLK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | BARX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | TOX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | NDF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ANS1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | SRSF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | PTN1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| CLK1_HUMAN | SRPK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZMAT2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZN765_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | SRSF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | 2A5D_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZSC18_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | TIF1B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ZN363_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | PNMA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | SRSF6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | ETS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | RNH2C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | HDAC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | CLK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | HSFY1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | PMF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05134 | Legionellosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0043484 | regulation of RNA splicing | IMP | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004715 | non-membrane spanning protein tyrosine kinase acti | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0046777 | protein autophosphorylation | IEA | biological_process |
| GO:0018107 | peptidyl-threonine phosphorylation | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |