| UniProt/SwissProt ID: | SRSF6_HUMAN |
| Description: | serine/arginine-rich splicing factor 6 [Source:HGNC Symbol;Acc:10788] |
| Location: | chr20 q13.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S196 | YSGSRsRSRSR | PhosphoSitePlus | |
| S295 | KSKSRsRSQSR | PhosphoSitePlus; HPRD | |
| S265 | HSRSRsKDEYE | PhosphoSitePlus; HPRD | |
| Y53 | ADDAVyELNGK | RRM_1 | PhosphoSitePlus |
| S253 | KSKPKsDRGSH | PhosphoSitePlus | |
| T323 | PPKRAtSRSRS | HPRD | |
| S324 | PKRATsRSRSR | HPRD | |
| Y191 | SHRRSySGSRS | PhosphoSitePlus | |
| S301 | RSQSRsNSPLP | PhosphoSitePlus; HPRD; phosphoELM | |
| S257 | KSDRGsHSHSR | PhosphoSitePlus; HPRD | |
| S316 | KARSVsPPPKR | PhosphoSitePlus; HPRD; phosphoELM | |
| S122 | LSSRCsWQDLK | RRM_1 | PhosphoSitePlus |
| S314 | PSKARsVSPPP | PhosphoSitePlus; HPRD; phosphoELM | |
| S293 | DIKSKsRSRSQ | PhosphoSitePlus | |
| S190 | TSHRRsYSGSR | PhosphoSitePlus | |
| S45 | VEFEDsRDADD | HPRD; phosphoELM | |
| S45 | VEFEDsRDADD | RRM_1 | PhosphoSitePlus |
| S297 | KSRSRsQSRSN | PhosphoSitePlus; HPRD; phosphoELM | |
| S194 | RSYSGsRSRSR | PhosphoSitePlus | |
| S259 | DRGSHsHSRSR | PhosphoSitePlus; HPRD; phosphoELM | |
| S326 | RATSRsRSRSR | PhosphoSitePlus; HPRD | |
| Y80 | RDRDGySYGSR | PhosphoSitePlus | |
| S119 | VENLSsRCSWQ | HPRD | |
| S310 | LPVPPsKARSV | PhosphoSitePlus | |
| T146 | AHKERtNEGVI | RRM_1 | PhosphoSitePlus |
| S84 | GYSYGsRSGGG | PhosphoSitePlus | |
| S299 | RSRSQsRSNSP | PhosphoSitePlus; HPRD; phosphoELM | |
| S263 | HSHSRsRSKDE | HPRD | |
| S118 | IVENLsSRCSW | HPRD | |
| S86 | SYGSRsGGGGY | PhosphoSitePlus | |
| S118 | IVENLsSRCSW | RRM_1 | PhosphoSitePlus |
| Y138 | AGEVTyADAHK | RRM_1 | PhosphoSitePlus |
| Y91 | SGGGGySSRRT | PhosphoSitePlus | |
| S303 | QSRSNsPLPVP | PhosphoSitePlus; HPRD; phosphoELM | |
| S291 | KGDIKsKSRSR | PhosphoSitePlus | |
| S81 | DRDGYsYGSRS | PhosphoSitePlus; HPRD | |
| Y82 | RDGYSyGSRSG | PhosphoSitePlus | |
| S97 | SSRRTsGRDKY | PhosphoSitePlus | |
| S119 | VENLSsRCSWQ | RRM_1 | PhosphoSitePlus |
| S261 | GSHSHsRSRSK | HPRD | |
| S192 | HRRSYsGSRSR | PhosphoSitePlus | |
| Dephosphorylation site |
| SRSF6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000244020 | R145Q | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000244020 | S236P | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000244020 | R321K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000244020 | R145Q | HPI | Colorectal Cancer | 16959974 |
| Differential expressed protein |
| SRSF6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SRSF6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK1_HUMAN | SRSF6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SRSF6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006369 | termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006376 | mRNA splice site selection | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0048025 | negative regulation of mRNA splicing, via spliceos | IDA | biological_process |
| GO:0031124 | mRNA 3'-end processing | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0006406 | mRNA export from nucleus | TAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |