| UniProt/SwissProt ID: | FA9_HUMAN |
| Description: | coagulation factor IX [Source:HGNC Symbol;Acc:3551] |
| Location: | chrX q27.1 |
| Node attribute: | ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S204 | VDYVNsTEAET | PhosphoSitePlus | |
| S114 | KDDINsYECWC | phosphoELM | |
| Dephosphorylation site |
| FA9_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000218099 | S156T | COSMIC | Lung Cancer | ENSP00000218099 | E323K | COSMIC | Lung Cancer | ENSP00000218099 | K109N | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000218099 | E10K | COSMIC | Skin Cancer | 21984974 | ENSP00000218099 | K109N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000218099 | G421R | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000218099 | E76Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| FA9_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FA9_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FA9_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| CEBPA_HUMAN | FA9_HUMAN | TF -> target gene | TRANSFAC |
| ANDR_HUMAN | FA9_HUMAN | TF -> target gene | TRANSFAC |
| COT2_HUMAN | FA9_HUMAN | TF -> target gene | TRANSFAC |
| COT1_HUMAN | FA9_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043687 | post-translational protein modification | TAS | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0007596 | blood coagulation | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0007598 | blood coagulation, extrinsic pathway | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007597 | blood coagulation, intrinsic pathway | TAS | biological_process |
| GO:0008233 | peptidase activity | IEA | molecular_function |
| GO:0004252 | serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0006508 | proteolysis | TAS | biological_process |
| GO:0005788 | endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0017187 | peptidyl-glutamic acid carboxylation | TAS | biological_process |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |