Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RNF6_HUMAN
Description:ring finger protein (C3H2C3 type) 6 [Source:HGNC Symbol;Acc:10069]
Location:chr13 q12.13
Node attribute:ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T133QNGNQtWRAVSPhosphoSitePlus
S6MNQSRsRSDGGPhosphoSitePlus
T389SSRSStAVRRHPhosphoSitePlus
S546QAQGDsTEMHGPhosphoSitePlus
S368AYTPFsNSRLVPhosphoSitePlus
S370TPFSNsRLVSRPhosphoSitePlus
S387EESSRsSTAVRPhosphoSitePlus
S340QTTRRsVRRRGPhosphoSitePlus
T547AQGDStEMHGEPhosphoSitePlus
T365RGTAYtPFSNSPhosphoSitePlus
Y364RRGTAyTPFSNPhosphoSitePlus
S468PLRRIsENELVPhosphoSitePlus
S476ELVEPsSVALRPhosphoSitePlus

Dephosphorylation site
RNF6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000371000T124ACOSMICOvarian Cancer21720365
ENSP00000342121A242TOMIMEsophageal Cancer12154016
ENSP00000371000A242TOMIMEsophageal Cancer12154016
ENSP00000370982R102KOMIMEsophageal Cancer12154016
ENSP00000371000R102KOMIMEsophageal Cancer12154016
ENSP00000371000T290SCOSMICMelanoma21499247
ENSP00000370982G244DOMIMEsophageal Cancer12154016
ENSP00000342121T389SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000370982T124ACOSMICOvarian Cancer21720365
ENSP00000371000H165DBIOMARTBreast Cancer21930507, 21930502
ENSP00000370982H165DBIOMARTBreast Cancer21930507, 21930502
ENSP00000342121T290SCOSMICMelanoma21499247
ENSP00000342121T124ACOSMICOvarian Cancer21720365
ENSP00000370982A242TOMIMEsophageal Cancer12154016
ENSP00000370982T389SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000371000G244DOMIMEsophageal Cancer12154016
ENSP00000371000T389SBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000342121R102KOMIMEsophageal Cancer12154016
ENSP00000342121G244DOMIMEsophageal Cancer12154016
ENSP00000342121H165DBIOMARTBreast Cancer21930507, 21930502
ENSP00000370982T290SCOSMICMelanoma21499247

Differential expressed protein
RNF6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RNF6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RNF6_HUMANANDR_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
RNF6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0060765regulation of androgen receptor signaling pathwayIMPbiological_process
GO:0006511ubiquitin-dependent protein catabolic processISSbiological_process
GO:0030424axonIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0044314protein K27-linked ubiquitinationIDAbiological_process
GO:0070936protein K48-linked ubiquitinationISSbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0030517negative regulation of axon extensionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0030517negative regulation of axon extensionISSbiological_process
GO:0050681androgen receptor bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0004842ubiquitin-protein ligase activityIMPmolecular_function
GO:0085020protein K6-linked ubiquitinationIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0070936protein K48-linked ubiquitinationIEAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030424axonISScellular_component