Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KLK3_HUMAN
Description:kallikrein-related peptidase 3 [Source:HGNC Symbol;Acc:6364]
Location:chr19 q13.33
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T167PEEFLtPKKLQHPRD
T124PEEFLtPKKLQHPRD
T143VMDLPtQEPALTrypsinPhosphoSitePlus
T100VMDLPtQEPALHPRD
T167PEEFLtPKKLQTrypsinPhosphoSitePlus
T143VMDLPtQEPALHPRD

Dephosphorylation site
KLK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000314151R45HBIOMARTBreast Cancer21930507, 21930502
ENSP00000314151H78QCOSMICOvarian Cancer21720365
ENSP00000314151A235VCOSMICHead and Neck Cancer21798897
ENSP00000314151E238KCOSMICRenal Cancer20054297

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000314151Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)cell lineUp3.514729644

Hyperphosphorylation site
KLK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANDR_HUMANKLK3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KLK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0008236serine-type peptidase activityTASmolecular_function
GO:0016525negative regulation of angiogenesisNASbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0004252serine-type endopeptidase activityIEAmolecular_function


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