Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AAKG2_HUMAN
Description:protein kinase, AMP-activated, gamma 2 non-catalytic subunit [Source:HGNC Symbol;Acc:9386]
Location:chr7 q36.1
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S143SNPATsPGGIRPhosphoSitePlus; HPRD; SysPTM
S85SGIFRsSSKESHPRD
S91SSKESsPNSNPHPRD
T121SSSPStPTQVTHPRD
S113RSRKTsGLSSSHPRD
S94ESSPNsNPATSHPRD
S152IYASSsPPDTGHPRD
S135SSKESsPNSNPHPRD
S131IFRSSsKESSPPhosphoSitePlus
S196IYASSsPPDTGPhosphoSitePlus; HPRD; SysPTM
S162SGLSSsPSTPTPhosphoSitePlus; HPRD; phosphoELM
S99SNPATsPGGIRHPRD
T97PVRPKtSPGSPPhosphoSitePlus
S98VRPKTsPGSPKPhosphoSitePlus
S73GPGSPsKGFFSPhosphoSitePlus
S161TSGLSsSPSTPHPRD
Y180FPLESyKHEPEPhosphoSitePlus
S138ESSPNsNPATSHPRD
S130GIFRSsSKESSHPRD
S86GIFRSsSKESSHPRD
T126TPTQVtKQHTFHPRD
T123SPSTPtQVTKQHPRD
S129SGIFRsSSKESHPRD
S90PSSPMsAPVRPPhosphoSitePlus
S160KTSGLsSSPSTPhosphoSitePlus
S117TSGLSsSPSTPHPRD
S151GIRFFsRSRKTPhosphoSitePlus
T170TPTQVtKQHTFHPRD
S118SGLSSsPSTPTHPRD
S65SRKVDsPFGPGPhosphoSitePlus
S87QPRPSsPMSAPPhosphoSitePlus
S120LSSSPsTPTQVHPRD
S32SQKRRsLRVHIPhosphoSitePlus
S71PFGPGsPSKGFPhosphoSitePlus; HPRD; SysPTM
S153RFFSRsRKTSGPhosphoSitePlus
S164LSSSPsTPTQVPhosphoSitePlus; HPRD
T167SPSTPtQVTKQPhosphoSitePlus; HPRD; phosphoELM
S157RSRKTsGLSSSPhosphoSitePlus; HPRD; phosphoELM
T165SSSPStPTQVTPhosphoSitePlus; HPRD
T156SRSRKtSGLSSPhosphoSitePlus
S101KTSPGsPKTVFPhosphoSitePlus
S122SPRRMsFSGIFPhosphoSitePlus
S27PFGPGsPSKGFHPRD

Dephosphorylation site
AAKG2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000287878Q337RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000387386Q96RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000287878L532FCOSMICBreast Cancer20668451
ENSP00000287878G300SCOSMICHead and Neck Cancer21798893
ENSP00000287878E254QBIOMARTBreast Cancer21930507, 21930502
ENSP00000287878F149VCOSMICRenal Cancer
ENSP00000376549Q293RBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
AAKG2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AAKG2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KKCC2_HUMANAAKG2_HUMANkinase -> substrateKEGG
AAKG2_HUMANACACA_HUMANkinase -> substrateKEGG
AAKG2_HUMANACACB_HUMANkinase -> substrateKEGG
AAKG2_HUMANPCKGC_HUMANotherKEGG
STAT3_HUMANAAKG2_HUMANotherKEGG
AAKG2_HUMANG6PC_HUMANotherKEGG
AAKG2_HUMANGTR1_HUMANotherKEGG
AAKG2_HUMANAGRP_HUMANotherKEGG
AAKG2_HUMANNPY_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019217regulation of fatty acid metabolic processIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0007243intracellular protein kinase cascadeIMPbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0004862cAMP-dependent protein kinase inhibitor activityIDAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006469negative regulation of protein kinase activityIDAbiological_process
GO:0005977glycogen metabolic processIMPbiological_process
GO:0006853carnitine shuttleTASbiological_process
GO:0046324regulation of glucose importTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010800positive regulation of peptidyl-threonine phosphorIMPbiological_process
GO:0016126sterol biosynthetic processTASbiological_process
GO:0042304regulation of fatty acid biosynthetic processTASbiological_process
GO:0006754ATP biosynthetic processTASbiological_process
GO:0031588AMP-activated protein kinase complexIDAcellular_component
GO:0006110regulation of glycolysisIMPbiological_process
GO:0008607phosphorylase kinase regulator activityIMPmolecular_function
GO:0043531ADP bindingIDAmolecular_function
GO:0030295protein kinase activator activityIMPmolecular_function
GO:0006633fatty acid biosynthetic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0019901protein kinase bindingIDAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0046320regulation of fatty acid oxidationTASbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0045860positive regulation of protein kinase activityIMPbiological_process
GO:0007050cell cycle arrestTASbiological_process
GO:0008603cAMP-dependent protein kinase regulator activityIMPmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process


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