UniProt/SwissProt ID: | AAKG2_HUMAN |
Description: | protein kinase, AMP-activated, gamma 2 non-catalytic subunit [Source:HGNC Symbol;Acc:9386] |
Location: | chr7 q36.1 |
Node attribute: | PPI(target); substrate; kinase; PPI(source) |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S143 | SNPATsPGGIR | PhosphoSitePlus; HPRD; SysPTM | |
S85 | SGIFRsSSKES | HPRD | |
S91 | SSKESsPNSNP | HPRD | |
T121 | SSSPStPTQVT | HPRD | |
S113 | RSRKTsGLSSS | HPRD | |
S94 | ESSPNsNPATS | HPRD | |
S152 | IYASSsPPDTG | HPRD | |
S135 | SSKESsPNSNP | HPRD | |
S131 | IFRSSsKESSP | PhosphoSitePlus | |
S196 | IYASSsPPDTG | PhosphoSitePlus; HPRD; SysPTM | |
S162 | SGLSSsPSTPT | PhosphoSitePlus; HPRD; phosphoELM | |
S99 | SNPATsPGGIR | HPRD | |
T97 | PVRPKtSPGSP | PhosphoSitePlus | |
S98 | VRPKTsPGSPK | PhosphoSitePlus | |
S73 | GPGSPsKGFFS | PhosphoSitePlus | |
S161 | TSGLSsSPSTP | HPRD | |
Y180 | FPLESyKHEPE | PhosphoSitePlus | |
S138 | ESSPNsNPATS | HPRD | |
S130 | GIFRSsSKESS | HPRD | |
S86 | GIFRSsSKESS | HPRD | |
T126 | TPTQVtKQHTF | HPRD | |
T123 | SPSTPtQVTKQ | HPRD | |
S129 | SGIFRsSSKES | HPRD | |
S90 | PSSPMsAPVRP | PhosphoSitePlus | |
S160 | KTSGLsSSPST | PhosphoSitePlus | |
S117 | TSGLSsSPSTP | HPRD | |
S151 | GIRFFsRSRKT | PhosphoSitePlus | |
T170 | TPTQVtKQHTF | HPRD | |
S118 | SGLSSsPSTPT | HPRD | |
S65 | SRKVDsPFGPG | PhosphoSitePlus | |
S87 | QPRPSsPMSAP | PhosphoSitePlus | |
S120 | LSSSPsTPTQV | HPRD | |
S32 | SQKRRsLRVHI | PhosphoSitePlus | |
S71 | PFGPGsPSKGF | PhosphoSitePlus; HPRD; SysPTM | |
S153 | RFFSRsRKTSG | PhosphoSitePlus | |
S164 | LSSSPsTPTQV | PhosphoSitePlus; HPRD | |
T167 | SPSTPtQVTKQ | PhosphoSitePlus; HPRD; phosphoELM | |
S157 | RSRKTsGLSSS | PhosphoSitePlus; HPRD; phosphoELM | |
T165 | SSSPStPTQVT | PhosphoSitePlus; HPRD | |
T156 | SRSRKtSGLSS | PhosphoSitePlus | |
S101 | KTSPGsPKTVF | PhosphoSitePlus | |
S122 | SPRRMsFSGIF | PhosphoSitePlus | |
S27 | PFGPGsPSKGF | HPRD | |
Dephosphorylation site |
AAKG2_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000287878 | Q337R | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000387386 | Q96R | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
ENSP00000287878 | L532F | COSMIC | Breast Cancer | 20668451 |
ENSP00000287878 | G300S | COSMIC | Head and Neck Cancer | 21798893 |
ENSP00000287878 | E254Q | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000287878 | F149V | COSMIC | Renal Cancer | |
ENSP00000376549 | Q293R | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
Differential expressed protein |
AAKG2_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
AAKG2_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
KKCC2_HUMAN | AAKG2_HUMAN | kinase -> substrate | KEGG |
AAKG2_HUMAN | ACACA_HUMAN | kinase -> substrate | KEGG |
AAKG2_HUMAN | ACACB_HUMAN | kinase -> substrate | KEGG |
AAKG2_HUMAN | PCKGC_HUMAN | other | KEGG |
STAT3_HUMAN | AAKG2_HUMAN | other | KEGG |
AAKG2_HUMAN | G6PC_HUMAN | other | KEGG |
AAKG2_HUMAN | GTR1_HUMAN | other | KEGG |
AAKG2_HUMAN | AGRP_HUMAN | other | KEGG |
AAKG2_HUMAN | NPY_HUMAN | other | KEGG |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04910 | Insulin signaling pathway |
hsa04920 | Adipocytokine signaling pathway |
hsa05410 | Hypertrophic cardiomyopathy (HCM) |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0019217 | regulation of fatty acid metabolic process | IMP | biological_process |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0007243 | intracellular protein kinase cascade | IMP | biological_process |
GO:0005524 | ATP binding | IDA | molecular_function |
GO:0004862 | cAMP-dependent protein kinase inhibitor activity | IDA | molecular_function |
GO:0005654 | nucleoplasm | TAS | cellular_component |
GO:0006469 | negative regulation of protein kinase activity | IDA | biological_process |
GO:0005977 | glycogen metabolic process | IMP | biological_process |
GO:0006853 | carnitine shuttle | TAS | biological_process |
GO:0046324 | regulation of glucose import | TAS | biological_process |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0010800 | positive regulation of peptidyl-threonine phosphor | IMP | biological_process |
GO:0016126 | sterol biosynthetic process | TAS | biological_process |
GO:0042304 | regulation of fatty acid biosynthetic process | TAS | biological_process |
GO:0006754 | ATP biosynthetic process | TAS | biological_process |
GO:0031588 | AMP-activated protein kinase complex | IDA | cellular_component |
GO:0006110 | regulation of glycolysis | IMP | biological_process |
GO:0008607 | phosphorylase kinase regulator activity | IMP | molecular_function |
GO:0043531 | ADP binding | IDA | molecular_function |
GO:0030295 | protein kinase activator activity | IMP | molecular_function |
GO:0006633 | fatty acid biosynthetic process | IEA | biological_process |
GO:0044281 | small molecule metabolic process | TAS | biological_process |
GO:0019901 | protein kinase binding | IDA | molecular_function |
GO:0006112 | energy reserve metabolic process | TAS | biological_process |
GO:0046320 | regulation of fatty acid oxidation | TAS | biological_process |
GO:0044255 | cellular lipid metabolic process | TAS | biological_process |
GO:0045860 | positive regulation of protein kinase activity | IMP | biological_process |
GO:0007050 | cell cycle arrest | TAS | biological_process |
GO:0008603 | cAMP-dependent protein kinase regulator activity | IMP | molecular_function |
GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |