Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	IRF1_HUMAN
Description:	interferon regulatory factor 1 [Source:HGNC Symbol;Acc:6116]
Location:	chr5 q31.1
Node attribute:	gene; TF

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y109	SAVRVyRMLPP	IRF	PhosphoSitePlus
T62	SWAIHtGRYKA		HPRD

Dephosphorylation site

IRF1_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000384406	W11R	OMIM	Non-small cell lung carcinoma	10395927
ENSP00000384406	Y65*	COSMIC	Lymphoma	21995386
ENSP00000245414	M8L	OMIM, HPI	Gastric Cancer	9679752
ENSP00000384406	M8L	OMIM, HPI	Gastric Cancer	9679752
ENSP00000245414	W11R	OMIM	Non-small cell lung carcinoma	10395927
ENSP00000245414	Y65*	COSMIC	Lymphoma	21995386
ENSP00000245414	W11R	HPI	Gastric Cancer	10395927
ENSP00000384406	W11R	HPI	Gastric Cancer	10395927

Differential expressed protein

IRF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

IRF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
STAT1_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	CY24B_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	I18BP_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	CCL5_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	ISG15_HUMAN	TF -> target gene	TRANSFAC
STAT3_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	IFNA1_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	IFIT2_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	IFM1_HUMAN	TF -> target gene	TRANSFAC
STAT4_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	C2TA_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	U627C_HUMAN	TF -> target gene	TRANSFAC
STA5A_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	IFNB_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	HLAG_HUMAN	TF -> target gene	TRANSFAC
IRF1_HUMAN	SLPI_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

IRF1_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0002819	regulation of adaptive immune response	TAS	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IMP	biological_process
GO:0000975	regulatory region DNA binding	IEA	molecular_function
GO:0045892	negative regulation of transcription, DNA-dependen	IMP	biological_process
GO:0043374	CD8-positive, alpha-beta T cell differentiation	IEA	biological_process
GO:0019221	cytokine-mediated signaling pathway	TAS	biological_process
GO:0008285	negative regulation of cell proliferation	TAS	biological_process
GO:0006366	transcription from RNA polymerase II promoter	TAS	biological_process
GO:0003700	sequence-specific DNA binding transcription factor	IEA	molecular_function
GO:0051607	defense response to virus	IDA	biological_process
GO:0005634	nucleus	TAS	cellular_component
GO:0003677	DNA binding	TAS	molecular_function
GO:0060333	interferon-gamma-mediated signaling pathway	IEA	biological_process
GO:0010468	regulation of gene expression	IEA	biological_process
GO:0045590	negative regulation of regulatory T cell different	IEA	biological_process
GO:0007596	blood coagulation	TAS	biological_process
GO:0032481	positive regulation of type I interferon productio	IEA	biological_process
GO:0035458	cellular response to interferon-beta	IDA	biological_process
GO:0007050	cell cycle arrest	IDA	biological_process
GO:0000790	nuclear chromatin	IDA	cellular_component
GO:0034124	regulation of MyD88-dependent toll-like receptor s	IEA	biological_process
GO:0051726	regulation of cell cycle	TAS	biological_process
GO:0000978	RNA polymerase II core promoter proximal region se	IDA	molecular_function
GO:0045088	regulation of innate immune response	TAS	biological_process
GO:0045893	positive regulation of transcription, DNA-dependen	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0003677	DNA binding	IEA	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0045084	positive regulation of interleukin-12 biosynthetic	IEA	biological_process
GO:0005737	cytoplasm	IEA	cellular_component
GO:0032728	positive regulation of interferon-beta production	IMP	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0060337	type I interferon-mediated signaling pathway	TAS	biological_process
GO:0006917	induction of apoptosis	IDA	biological_process
GO:0043565	sequence-specific DNA binding	IEA	molecular_function
GO:0005654	nucleoplasm	TAS	cellular_component
GO:2000564	regulation of CD8-positive, alpha-beta T cell prol	IEA	biological_process
GO:0071260	cellular response to mechanical stimulus	IEP	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0006473	protein acetylation	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network