Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGFR3_HUMAN
Description:fibroblast growth factor receptor 3 [Source:HGNC Symbol;Acc:3690]
Location:chr4 p16.3
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y648TSTDEyLDLSAFGFR3HPRD
Y648HNLDYyKKTTNPkinase_TyrPhosphoSitePlus
T338SGEGPtLANVSHPRD
S466PGLDYsFDTCKHPRD
S445IARLSsGEGPTPhosphoSitePlus; HPRD; phosphoELM
Y648HNLDYyKKTTNFGFR3HPRD; phosphoELM; RegPhos
Y577PPGLDySFDTCPkinase_TyrPhosphoSitePlus
S596FKDLVsCAYQVPkinase_TyrPhosphoSitePlus
Y465PPGLDySFDTCFGFR3HPRD
Y724CTHDLyMIMREFGFR3HPRD; phosphoELM; RegPhos
Y535VHNLDyYKKTTFGFR3HPRD
Y647VHNLDyYKKTTRegPhos
T777PGGQDtPSSSSPhosphoSitePlus
S578PGLDYsFDTCKPkinase_TyrPhosphoSitePlus
Y760TSTDEyLDLSAFGFR3HPRD; phosphoELM; RegPhos
Y607ARGMEyLASQKPkinase_TyrPhosphoSitePlus
Y658APFEQySPGGQFGFR3HPRD
Y612CTHDLyMIMREFGFR3HPRD
Y599LVSCAyQVARGPkinase_TyrPhosphoSitePlus
S524LSDLVsEMEMMPkinase_TyrPhosphoSitePlus
Y770APFEQySPGGQPhosphoSitePlus
S444RIARLsSGEGPPhosphoSitePlus; HPRD; phosphoELM
S578PGLDYsFDTCKHPRD
Y647VHNLDyYKKTTFGFR3HPRD; phosphoELM; RegPhos
Y724CTHDLyMIMREPkinase_TyrPhosphoSitePlus
Y536HNLDYyKKTTNFGFR3HPRD
T450SGEGPtLANVSHPRD; phosphoELM
Y647VHNLDyYKKTTPkinase_TyrPhosphoSitePlus
S787SSGDDsVFAHDPhosphoSitePlus
S332RIARLsSGEGPHPRD
Y770APFEQySPGGQFGFR3HPRD; phosphoELM; RegPhos
Y760TSTDEyLDLSAPhosphoSitePlus
S333IARLSsGEGPTHPRD
Y577PPGLDySFDTCFGFR3HPRD; phosphoELM; RegPhos
Y648HNLDYyKKTTNautocatalysis RegPhos

Dephosphorylation site
FGFR3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260795K650EGreenman2007Urinary Bladder Cancer10471491, 11157491, 11314002, 11395371, 11429702, 11529856, 11745189, 12139740, 12743143, 14678961, 15026322, 15772091, 15897885, 16040860, 16778799, 16885334, 17344846, 17392824, 17585316, 17668422, 18231634, 18428421, 9207791, 9763594
ENSP00000414914S249COMIM, HPIUterine Cancer10471491 15772091, 8589699 8845844 10360402 10471491 15772091 22229528 21264819 20664185 20542753 19749790 19845664 19722178 19663703 19449430 19377444 17384684 16877735 16338952 16144932 15869706 15772091 11879084 11466624 11395371 11904459
ENSP00000260795C228RGreenman2007Intestines Cancer17344846, 18428421
ENSP00000414914K650QHPIUrinary Bladder Cancer11055896 11314002 20453470 19722178 18000903 21510009
ENSP00000414914E322KOMIM, HPIColorectal Cancer11325814
ENSP00000414914T79SHPILung Cancer17344846
ENSP00000414914P572ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000414914G370CHPIUrinary Bladder Cancer8845844 9790257 10471491 15772091 16841094 20053668 18789890 16253490 12009017 10587515
ENSP00000260795K650EGreenman2007Neoplasms by Histologic Type10471491, 11157491, 11314002, 11395371, 11429702, 11529856, 11745189, 12139740, 12743143, 14678961, 15026322, 15772091, 15897885, 16040860, 16778799, 16885334, 17344846, 17392824, 17585316, 17668422, 18231634, 18428421, 9207791, 9763594
ENSP00000414914E466KBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000260795R248CHPIUrinary Bladder Cancer17509076 7773297 8845844 10360402 10471491 11529856 15772091 16841094 21639936 21253318 20711586 20420824 20569165 20542753 20704477 19845664 19722178 19449430 19327639 19287463 19088846 18642369 17673550 17509076 17441958 17255960 17048442 16841094
ENSP00000260795K650EGreenman2007Other Cancer(urinary_tract cancer)10471491, 11157491, 11314002, 11395371, 11429702, 11529856, 11745189, 12139740, 12743143, 14678961, 15026322, 15772091, 15897885, 16040860, 16778799, 16885334, 17344846, 17392824, 17585316, 17668422, 18231634, 18428421, 9207791, 9763594
ENSP00000414914K650TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000260795K650TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000260795S249COMIMUrinary Bladder Cancer10471491 15772091
ENSP00000260795P572ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000414914R248CHPIUrinary Bladder Cancer17509076 7773297 8845844 10360402 10471491 11529856 15772091 16841094 21639936 21253318 20711586 20420824 20569165 20542753 20704477 19845664 19722178 19449430 19327639 19287463 19088846 18642369 17673550 17509076 17441958 17255960 17048442 16841094
ENSP00000260795C228RHPIColorectal Cancer17344846
ENSP00000260795P460ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000414914C228RHPIColorectal Cancer17344846
ENSP00000260795K650QHPIUrinary Bladder Cancer11055896 11314002 20453470 19722178 18000903 21510009
ENSP00000260795S249COMIM, HPIUterine Cancer10471491 15772091, 8589699 8845844 10360402 10471491 15772091 22229528 21264819 20664185 20542753 19749790 19845664 19722178 19663703 19449430 19377444 17384684 16877735 16338952 16144932 15869706 15772091 11879084 11466624 11395371 11904459
ENSP00000260795K650EGreenman2007Skin Cancer10471491, 11157491, 11314002, 11395371, 11429702, 11529856, 11745189, 12139740, 12743143, 14678961, 15026322, 15772091, 15897885, 16040860, 16778799, 16885334, 17344846, 17392824, 17585316, 17668422, 18231634, 18428421, 9207791, 9763594
ENSP00000260795E322KOMIM, HPIColorectal Cancer11325814
ENSP00000260795T79SGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000260795G370CHPIUrinary Bladder Cancer8845844 9790257 10471491 15772091 16841094 20053668 18789890 16253490 12009017 10587515
ENSP00000414914S249COMIMUrinary Bladder Cancer10471491 15772091
ENSP00000414914P460ATCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000414914Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
FGFR3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF2_HUMANFGFR3_HUMANligand -> receptorHPMR
FGF8_HUMANFGFR3_HUMANligand -> receptorHPMR
FGF4_HUMANFGFR3_HUMANligand -> receptorHPMR
FGF18_HUMANFGFR3_HUMANligand -> receptorHPMR
FGF9_HUMANFGFR3_HUMANligand -> receptorHPMR
ZAGL2_HUMANFGFR3_HUMANkinase -> substrateRegPhos
FGFR3_HUMANFGFR3_HUMANkinase -> substrateRegPhos
FGFR3_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
FGFR3_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04144Endocytosis
hsa04810Regulation of actin cytoskeleton
hsa05219Bladder cancer
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048640negative regulation of developmental growthISSbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaIDAbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0070307lens fiber cell developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0072148epithelial cell fate commitmentIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0060349bone morphogenesisTASbiological_process
GO:0003416endochondral bone growthTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0042511positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0090102cochlea developmentIEAbiological_process
GO:0002089lens morphogenesis in camera-type eyeIEAbiological_process
GO:0045839negative regulation of mitosisIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0035988chondrocyte proliferationTASbiological_process
GO:0090080positive regulation of MAPKKK cascade by fibroblasIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009898internal side of plasma membraneIEAcellular_component
GO:0005925focal adhesionTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0048712negative regulation of astrocyte differentiationIEAbiological_process
GO:0048678response to axon injuryIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0005007fibroblast growth factor-activated receptor activiIMPmolecular_function
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0014003oligodendrocyte developmentIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0005007fibroblast growth factor-activated receptor activiIEAmolecular_function
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0042981regulation of apoptotic processIMPbiological_process
GO:0045879negative regulation of smoothened signaling pathwaIEAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIMPbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0005764lysosomeIEAcellular_component
GO:0051216cartilage developmentIEAbiological_process
GO:0070977bone maturationISSbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0000165MAPK cascadeIEAbiological_process
GO:0002009morphogenesis of an epitheliumIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0060113inner ear receptor cell differentiationIEAbiological_process
GO:0010518positive regulation of phospholipase activityIMPbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0061144alveolar secondary septum developmentIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0001501skeletal system developmentTASbiological_process
GO:0031398positive regulation of protein ubiquitinationIEAbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0060349bone morphogenesisIEAbiological_process
GO:0060385axonogenesis involved in innervationIEAbiological_process
GO:0021762substantia nigra developmentIEAbiological_process
GO:0017134fibroblast growth factor bindingIDAmolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0002062chondrocyte differentiationTASbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0001958endochondral ossificationTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0022010central nervous system myelinationIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process