Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INAR1_HUMAN
Description:interferon (alpha, beta and omega) receptor 1 [Source:HGNC Symbol;Acc:5432]
Location:chr21 q22.11
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S532YSSQTsQDSGNPhosphoSitePlus
Y466LRCINyVFFPSTyk2phosphoELM; RegPhos
Y481SSIDEyFSEQPTyk2phosphoELM; RegPhos
S539DSGNYsNEDESHPRD; RegPhos
Y466LRCINyVFFPSPhosphoSitePlus
Y538QDSGNySNEDEPhosphoSitePlus
T494NLLLStSEEQIHPRD
Y466LRCINyVFFPSTYK2HPRD; RegPhos
S495LLLSTsEEQIEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T85QNITStKCNFSTissue_facPhosphoSitePlus
Y481SSIDEyFSEQPPhosphoSitePlus
S535QTSQDsGNYSNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y481SSIDEyFSEQPTYK2HPRD; RegPhos

Dephosphorylation site
INAR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000270139M255ICOSMICCentral Nervous System Neoplasms18772396
ENSP00000270139I41VCOSMICHepatocellular Carcinoma21822264
ENSP00000270139Q498KCOSMICMelanoma21499247
ENSP00000270139I339VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
INAR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
INAR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANINAR1_HUMANkinase -> substrateRegPhos
TYK2_HUMANINAR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
IFNB_HUMANINAR1_HUMANotherKEGG
INAR1_HUMANSTAT1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04060Cytokine-cytokine receptor interaction
hsa05160Hepatitis C
hsa05168Herpes simplex infection
hsa04650Natural killer cell mediated cytotoxicity
hsa04630Jak-STAT signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa05164Influenza A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045351type I interferon biosynthetic processIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0009615response to virusTASbiological_process
GO:0004905type I interferon receptor activityTASmolecular_function
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0004904interferon receptor activityIEAmolecular_function
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042110T cell activationIEAbiological_process


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