| UniProt/SwissProt ID: | INAR1_HUMAN |
| Description: | interferon (alpha, beta and omega) receptor 1 [Source:HGNC Symbol;Acc:5432] |
| Location: | chr21 q22.11 |
| Node attribute: | PPI(target); substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S532 | YSSQTsQDSGN | PhosphoSitePlus | |
| Y466 | LRCINyVFFPS | Tyk2 | phosphoELM; RegPhos |
| Y481 | SSIDEyFSEQP | Tyk2 | phosphoELM; RegPhos |
| S539 | DSGNYsNEDES | HPRD; RegPhos | |
| Y466 | LRCINyVFFPS | PhosphoSitePlus | |
| Y538 | QDSGNySNEDE | PhosphoSitePlus | |
| T494 | NLLLStSEEQI | HPRD | |
| Y466 | LRCINyVFFPS | TYK2 | HPRD; RegPhos |
| S495 | LLLSTsEEQIE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T85 | QNITStKCNFS | Tissue_fac | PhosphoSitePlus |
| Y481 | SSIDEyFSEQP | PhosphoSitePlus | |
| S535 | QTSQDsGNYSN | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y481 | SSIDEyFSEQP | TYK2 | HPRD; RegPhos |
| Dephosphorylation site |
| INAR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000270139 | M255I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000270139 | I41V | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000270139 | Q498K | COSMIC | Melanoma | 21499247 | ENSP00000270139 | I339V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| INAR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| INAR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | INAR1_HUMAN | kinase -> substrate | RegPhos |
| TYK2_HUMAN | INAR1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| IFNB_HUMAN | INAR1_HUMAN | other | KEGG |
| INAR1_HUMAN | STAT1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05160 | Hepatitis C |
| hsa05168 | Herpes simplex infection |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04380 | Osteoclast differentiation |
| hsa04620 | Toll-like receptor signaling pathway |
| hsa05164 | Influenza A |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045351 | type I interferon biosynthetic process | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0009615 | response to virus | TAS | biological_process |
| GO:0004905 | type I interferon receptor activity | TAS | molecular_function |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0004904 | interferon receptor activity | IEA | molecular_function |
| GO:0032729 | positive regulation of interferon-gamma production | IEA | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0060338 | regulation of type I interferon-mediated signaling | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042110 | T cell activation | IEA | biological_process |