| UniProt/SwissProt ID: | CISH_HUMAN |
| Description: | cytokine inducible SH2-containing protein [Source:HGNC Symbol;Acc:1984] |
| Location: | chr3 p21.2 |
| Node attribute: | PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S175 | DTRSDsPDPAP | PhosphoSitePlus | |
| S173 | TADTRsDSPDP | PhosphoSitePlus | |
| Dephosphorylation site |
| CISH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000294173 | E44Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| CISH_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CISH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CISH_HUMAN | STAT1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0001558 | regulation of cell growth | NAS | biological_process |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0003674 | molecular_function | ND | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signal | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0009968 | negative regulation of signal transduction | IEA | biological_process |
| GO:0035556 | intracellular signal transduction | NAS | biological_process |