Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRPK2_HUMAN
Description:SRSF protein kinase 2 [Source:HGNC Symbol;Acc:11306]
Location:chr7 q22.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y427ESDYTySSSYEPhosphoSitePlus
T509VSASStGDLPKHPRD
T558TEDIQtRQYRSHPRD
T547TEDIQtRQYRSHPRD; SysPTM
S312TSAAPsNDQDGPhosphoSitePlus
Y319DQDGEyCPEVKPhosphoSitePlus; HPRD; phosphoELM
T503HDRSRtVSASSHPRD
Y425NAESDyTYSSSPhosphoSitePlus
Y431TYSSSyEQFNGPhosphoSitePlus
S495EQEESsPSHDRHPRD
S52EEILGsDDEEQPhosphoSitePlus
S380PTWIEsPKTNGPhosphoSitePlus; HPRD; SysPTM
S507RTVSAsSTGDLHPRD
Y330DQDGEyCPEVKHPRD
S10SEKSSsSERPEHPRD
T492HDRSRtVSASSPhosphoSitePlus; HPRD
S391PTWIEsPKTNGHPRD
T547TEDIQtRQYRSPkinasePhosphoSitePlus; SysPTM
S484EQEESsPSHDRPhosphoSitePlus; HPRD; phosphoELM
T498VSASStGDLPKPhosphoSitePlus; HPRD; phosphoELM
S483TEQEEsSPSHDPhosphoSitePlus; HPRD; phosphoELM
S494TEQEEsSPSHDHPRD; SysPTM
S497TVSASsTGDLPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S423EPNAEsDYTYSPhosphoSitePlus
Y182IIKSNyQGLPVPkinasePhosphoSitePlus
S496RTVSAsSTGDLPhosphoSitePlus; HPRD
S508TVSASsTGDLPHPRD
S505RSRTVsASSTGHPRD
S494RSRTVsASSTGPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
SRPK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000419791E167*COSMICHead and Neck Cancer21798897
ENSP00000377262E303KBIOMARTBreast Cancer21930507, 21930502
ENSP00000419791R519PCOSMICHead and Neck Cancer21798893
ENSP00000419791E292KBIOMARTBreast Cancer21930507, 21930502
ENSP00000419791Q480*COSMICOvarian Cancer
ENSP00000419791G243DHPINeoplasms by Histologic Type17344846
ENSP00000349863E292KBIOMARTBreast Cancer21930507, 21930502
ENSP00000349863R519PCOSMICHead and Neck Cancer21798893
ENSP00000349863Q480*COSMICOvarian Cancer
ENSP00000419791Q315HCOSMICOvarian Cancer21720365
ENSP00000419791G243DCOSMICCentral Nervous System Neoplasms16618716
ENSP00000419791G317DCOSMICCentral Nervous System Neoplasms18772396
ENSP00000349863G243DHPINeoplasms by Histologic Type17344846
ENSP00000349863E167*COSMICHead and Neck Cancer21798897
ENSP00000349863Q315HCOSMICOvarian Cancer21720365
ENSP00000349863G243DCOSMICCentral Nervous System Neoplasms16618716
ENSP00000349863G317DCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
SRPK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SRPK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRPK2_HUMANCSN6_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANKPCD_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANZRAB2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANDDX25_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANHIF1A_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANZCHC8_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSRSF2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SRPK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045087innate immune responseICbiological_process
GO:0005634nucleusIEAcellular_component
GO:0008380RNA splicingIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0000245spliceosomal complex assemblyIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processISSbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0008380RNA splicingIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:007188914-3-3 protein bindingISSmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0010628positive regulation of gene expressionISSbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0045787positive regulation of cell cycleIEAbiological_process
GO:0045070positive regulation of viral genome replicationIDAbiological_process
GO:0035063nuclear speck organizationISSbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0001525angiogenesisISSbiological_process
GO:0000245spliceosomal complex assemblyIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045071negative regulation of viral genome replicationIDAbiological_process
GO:0042981regulation of apoptotic processNASbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0035063nuclear speck organizationIEAbiological_process
GO:0045787positive regulation of cell cycleISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0048024regulation of mRNA splicing, via spliceosomeTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function