| UniProt/SwissProt ID: | ML12B_HUMAN |
| Description: | myosin, light chain 12B, regulatory [Source:HGNC Symbol;Acc:29827] |
| Location: | chr18 p11.31 |
| Node attribute: | PPI(source); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T19 | RPQRAtSNVFA | 2-Hacid_dh_C | PhosphoSitePlus |
| T135 | MGDRFtDEEVD | UPF0154; DUF1880 | PhosphoSitePlus |
| T10 | KAKTKtTKKRP | PhosphoSitePlus | |
| S29 | AMFDQsQIQEF | 2-Hacid_dh_C; EF_hand_5 | PhosphoSitePlus |
| T128 | LRELLtTMGDR | UPF0154 | PhosphoSitePlus |
| Y143 | EVDELyREAPI | UPF0154; DUF1880 | PhosphoSitePlus |
| S20 | PQRATsNVFAM | 2-Hacid_dh_C; EF_hand_5 | PhosphoSitePlus |
| Y156 | KGNFNyIEFTR | DUF1880 | PhosphoSitePlus |
| S60 | HDMLAsLGKNP | 2-Hacid_dh_C; EF_hand_5 | PhosphoSitePlus |
| S20 | PQRATsNVFAM | HPRD | |
| T19 | RPQRAtSNVFA | HPRD | |
| T11 | AKTKTtKKRPQ | PhosphoSitePlus | |
| Dephosphorylation site |
| ML12B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ML12B_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000383037 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 3.1 | 18646787 | ENSP00000383037 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.7 | 19098285 | ENSP00000383037 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Up | 2 | 20804217 | ENSP00000383037 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.8 | 20052998 | ENSP00000383037 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.8 | 20052998 | ENSP00000383037 | Breast Cancer | Metastasis | cell line | Up | 1.2 | 20052998 | ENSP00000383037 | Leukemia | Normal vs. Cancer | tissue | Down | 15501966 |
| Hyperphosphorylation site |
| ML12B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ROCK1_HUMAN | ML12B_HUMAN | kinase -> substrate | RegPhos |
| MYLK_HUMAN | ML12B_HUMAN | kinase -> substrate | KEGG |
| ZAGL2_HUMAN | ML12B_HUMAN | kinase -> substrate | RegPhos |
| MYPT1_HUMAN | ML12B_HUMAN | phosphatase -> substrate | KEGG |
| RHOA_HUMAN | ML12B_HUMAN | other | KEGG |
| ML12B_HUMAN | ACTG_HUMAN | other | KEGG |
| ROCK1_HUMAN | ML12B_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04670 | Leukocyte transendothelial migration |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04510 | Focal adhesion |
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008360 | regulation of cell shape | IEA | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0045177 | apical part of cell | IEA | cellular_component |
| GO:0016460 | myosin II complex | IEA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0001725 | stress fiber | IEA | cellular_component |
| GO:0006936 | muscle contraction | TAS | biological_process |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |