Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ML12B_HUMAN
Description:myosin, light chain 12B, regulatory [Source:HGNC Symbol;Acc:29827]
Location:chr18 p11.31
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T19RPQRAtSNVFA2-Hacid_dh_CPhosphoSitePlus
T135MGDRFtDEEVDUPF0154; DUF1880PhosphoSitePlus
T10KAKTKtTKKRPPhosphoSitePlus
S29AMFDQsQIQEF2-Hacid_dh_C; EF_hand_5PhosphoSitePlus
T128LRELLtTMGDRUPF0154PhosphoSitePlus
Y143EVDELyREAPIUPF0154; DUF1880PhosphoSitePlus
S20PQRATsNVFAM2-Hacid_dh_C; EF_hand_5PhosphoSitePlus
Y156KGNFNyIEFTRDUF1880PhosphoSitePlus
S60HDMLAsLGKNP2-Hacid_dh_C; EF_hand_5PhosphoSitePlus
S20PQRATsNVFAMHPRD
T19RPQRAtSNVFAHPRD
T11AKTKTtKKRPQPhosphoSitePlus

Dephosphorylation site
ML12B_HUMAN do not have dephosphorylation site.

Mutation site
ML12B_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000383037Hepatocellular CarcinomaNormal vs. Cancercell lineUp3.118646787
ENSP00000383037colorectal cancerNormal vs. CancertissueUp1.719098285
ENSP00000383037Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp220804217
ENSP00000383037Breast CancerNormal vs. Cancercell lineUp1.820052998
ENSP00000383037Breast CancerNormal vs. Cancercell lineUp1.820052998
ENSP00000383037Breast CancerMetastasiscell lineUp1.220052998
ENSP00000383037LeukemiaNormal vs. CancertissueDown15501966

Hyperphosphorylation site
ML12B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANML12B_HUMANkinase -> substrateRegPhos
MYLK_HUMANML12B_HUMANkinase -> substrateKEGG
ZAGL2_HUMANML12B_HUMANkinase -> substrateRegPhos
MYPT1_HUMANML12B_HUMANphosphatase -> substrateKEGG
RHOA_HUMANML12B_HUMANotherKEGG
ML12B_HUMANACTG_HUMANotherKEGG
ROCK1_HUMANML12B_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0008360regulation of cell shapeIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0045177apical part of cellIEAcellular_component
GO:0016460myosin II complexIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0001725stress fiberIEAcellular_component
GO:0006936muscle contractionTASbiological_process
GO:0030018Z discIEAcellular_component
GO:0005829cytosolTAScellular_component


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